Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,092 questions · 3,199 findings · 339 reviews · Headline outcomes only

No studies found 714 · 22.3%GRADE not reported 181 · 5.7%Very low 695 · 21.7%Low 908 · 28.4%Moderate 568 · 17.8%High 133 · 4.2%

Zinc vs placebo

Need for antibiotics days of antibiotic use · children with cystic fibrosis

It is very uncertain whether summary of findings: Zinc supplementation changes need for antibiotics number of days on IV or oral antibiotics compared with placebo (very low certainty).

1 finding from 1 review

Any systemic treatment vs placebo

Oral Tyrosine kinase 2 (TYK2) inhibitor · people with chronic plaque psoriasis

Any systemic treatment may leads to higher oral tyrosine kinase 2 (TYK2) inhibitor compared with placebo (low certainty).

2 findings from 1 review

Intervention not reported

Adverse effects Oral glucose tolerance test (mg/dL) (at one year) · people with thalassaemia (any age)
1 finding from 1 review

Primary objective: mobile stock notification with effective product transport vs usual care

Proportion of healthcare workers who reported a stockout of drugs in the last 30 days (stockout of oral rehydration salts (ORS) to treat dehydration) · healthcare workers and other health professionals involved in commodity and stock management

It is very uncertain whether primary objective: mobile stock notification with effective product… changes proportion of healthcare workers who reported a stockout of drugs in… compared with standard care (very low certainty).

1 finding from 1 review

Primary objective: mobile stock notification with enhanced management vs usual care

Proportion of healthcare workers who reported a stockout of drugs in the last 30 days (stockout of oral rehydration salts (ORS) to treat dehydration) · healthcare workers and other health professionals involved in commodity and stock management

It is very uncertain whether primary objective: mobile stock notification with enhanced management changes proportion of healthcare workers who reported a stockout of drugs in… compared with standard care (very low certainty).

1 finding from 1 review

Digital targeted client communication via mobile devices vs non‐digital targeted client communication (parents of children aged under five years)

Health behaviour change – hygiene practices · parents of children aged < 5 years

Digital targeted client communication via mobile devices showed no clear difference in health behaviour change – hygiene practices (oral health in children… compared with non‐digital targeted client communication (parents of children aged… (low certainty).

1 finding from 1 review

Digital targeted client communication via mobile devices vs standard skin care or no skin care intervention

Health behaviour change ‐ Oral contraception use · Adolescents and youth age 14 to 24 years

Digital targeted client communication via mobile devices may leads to higher health behaviour change ‐ Oral contraception use compared with standard care or no intervention (low certainty).

1 finding from 1 review

Comparison 1: route of antibiotic vs usual care

Neonatal mortality ‐ oral + injectable antibiotics · neonates with sepsis

Comparison 1: route of antibiotic showed no clear difference in neonatal mortality ‐ oral + injectable antibiotics compared with standard care (moderate certainty).

1 finding from 1 review

Tranexamic acid vs placebo + standard care

Control of epistaxis: episodes of re‐bleeding over 10 days All treatments (topical and oral) · adults with nasal haemorrhage (epistaxis)

Tranexamic acid probably leads to lower control of epistaxis: episodes of re‐bleeding over 10 days All… compared with placebo plus usual care or usual care alone (moderate certainty).

1 finding from 1 review