Cochrane · systematic review · CD004328
Tranexamic acid for patients with nasal haemorrhage (epistaxis)
Joseph, J, Martinez‐Devesa, P, Bellorini, J, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
ENTAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
6
No studies
3
Included studies
NR
No studies 3 · 25%Ungraded 3 · 25%Very low 0 · 0%Low 3 · 25%Moderate 3 · 25%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Tranexamic acid compared to placebo plus usual care or usual care alone for patients with nasal haemorrhage (epistaxis)
Population: adults with nasal haemorrhage (epistaxis)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Control of epistaxis: episodes of re‐bleeding over 10 days All treatments (topical and oral) Tranexamic acid vs placebo plus usual care or usual care alone | RR 0.71 [0.56, 0.9] | 3 studies · 225 participants | Moderate Downgraded: imprecision |
Control of epistaxis: episodes of re‐bleeding over 10 days Oral treatment only Tranexamic acid vs placebo plus usual care or usual care alone | RR 0.73 [0.55, 0.96] | 2 studies · 157 participants | Moderate Downgraded: imprecision |
Control of epistaxis: episodes of re‐bleeding over 10 days Topical application (10% gel) only Tranexamic acid vs placebo plus usual care or usual care alone | RR 0.66 [0.41, 1.05] | 1 study · 68 participants | Low Downgraded: risk of bias, imprecision |
Control of epistaxis: time to stop initial bleeding (proportion of patients whose bleeding is controlled in ≤ 30 minutes) Tranexamic acid vs placebo plus usual care or usual care alone | RR 0.79 [0.56, 1.11] | 1 study · 68 participants | Low Downgraded: risk of bias, imprecision |
Severity of re‐bleeding: proportion of patients requiring blood transfusion within 10 days Tranexamic acid vs placebo plus usual care or usual care alone | RR 0.81 [0.27, 2.48] | 1 study · 89 participants | Low Downgraded: risk of bias, imprecision |
Length of hospital stay Tranexamic acid vs placebo plus usual care or usual care alone | no estimate extracted | 2 studies · 157 participants | Ungraded |
Adverse effects: serious or other Tranexamic acid vs placebo plus usual care or usual care alone | no estimate extracted | NR | No studies |
Tranexamic acid compared to other haemostatic agent for patients with nasal haemorrhage (epistaxis)
Population: adults with nasal haemorrhage (epistaxis)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Control of epistaxis: episodes of re‐bleeding over 10 days Tranexamic acid vs other haemostatic agent | no estimate extracted | 10 participants | Ungraded |
Control of epistaxis: time to stop initial bleeding (proportion with bleeding controlled within 10 minutes) Tranexamic acid vs other haemostatic agent | RR 2.35 [1.9, 2.92] | 3 studies · 460 participants | Moderate Downgraded: risk of bias |
Severity of re‐bleeding: proportion of patients requiring blood transfusion within 10 days Tranexamic acid vs other haemostatic agent | no estimate extracted | NR | No studies |
Length of hospital stay Tranexamic acid vs other haemostatic agent | no estimate extracted | 10 participants | Ungraded |
Adverse effects: serious or other Tranexamic acid vs other haemostatic agent | no estimate extracted | NR | No studies |