Cochrane · systematic review · CD009628
Structural magnetic resonance imaging for the early diagnosis of dementia due to Alzheimer's disease in people with mild cognitive impairment
Lombardi, G, Crescioli, G, Cavedo, E, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Dementia and Cognitive ImprovementAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 40%Low 1 · 20%Moderate 2 · 40%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Whole brain volume or volume of specific brain regions for early Alzheimer's disease dementia diagnosis in people with mild cognitive impairment
Population: people with mild cognitive impairment (MCI)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total hippocampus | no estimate extracted | 22 studies · 2209 participants | Low Downgraded: risk of bias, imprecision |
Medial temporal lobe | no estimate extracted | 7 studies · 1077 participants | Moderate Downgraded: risk of bias, imprecision |
Lateral ventricles | no estimate extracted | 5 studies · 1077 participants | Moderate Downgraded: risk of bias, imprecision |
Total entorhinal cortex | no estimate extracted | 4 studies · 529 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Whole brain | no estimate extracted | 4 studies · 424 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |