Cochrane · systematic review · CD012284

Growth hormone therapy for people with thalassaemia

Ngim, CF, Lai, NM, Hong, JYH, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library

Cystic Fibrosis and Genetic Disorders2 versionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 6 · 85.7%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

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Growth hormone for people with thalassaemia

Population: people with thalassaemia (any age)
7 questions
OutcomeEffectEvidenceStatus / GRADE
Final height and change in height
no estimate extractedNRNo studies
Adverse effects Oral glucose tolerance test (mg/dL) (at one year)
no estimate extracted1 study · 20 participantsModerate
Downgraded: imprecision
Height SDS(at one year)
no estimate extracted1 study · 20 participantsModerate
Downgraded: imprecision
Change in height SDS (difference between baseline and final visit at one year)
no estimate extracted1 study · 20 participantsModerate
Downgraded: imprecision
Height velocity (cm/year)
no estimate extracted1 study · 20 participantsModerate
Downgraded: imprecision
Height velocity SDS
no estimate extracted1 study · 20 participantsModerate
Downgraded: imprecision
Change in height velocity SDS (difference between baseline and final visit at one year)
no estimate extracted1 study · 20 participantsModerate
Downgraded: imprecision