Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Every word you type has to appear somewhere in the question, and the closest matches are ranked first.

Limit to evidence status or GRADE (optional)

75,239 questions in 5,342 reviews

current versions
No studies 15,213 · 20.2%Ungraded 10,323 · 13.7%Very low 17,528 · 23.3%Low 17,951 · 23.9%Moderate 11,190 · 14.9%High 3,034 · 4%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Antibiotics vs surgery
Clostridium difficile diarrhoea · adults with uncomplicated appendicitis
Appendectomy versus antibiotic treatment for acute appendicitis (2024) · Cochrane
OR 0.97 [0.24, 3.89]3 studies · 1552 participantsVery low
Antibiotics vs surgery
Intra‐abdominal abscess or collection · adults with uncomplicated appendicitis
Appendectomy versus antibiotic treatment for acute appendicitis (2024) · Cochrane
RR 1.58 [0.61, 4.07]6 studies · 1831 participantsVery low
Antibiotics vs surgery
Reoperation · adults with uncomplicated appendicitis
Appendectomy versus antibiotic treatment for acute appendicitis (2024) · Cochrane
OR 0.13 [0.01, 2.16]1 study · 492 participantsVery low
Antibiotics vs surgery
Length of hospital stay (days) · adults with uncomplicated appendicitis
Appendectomy versus antibiotic treatment for acute appendicitis (2024) · Cochrane
MD 0.54 [0.06, 1.01]11 studies · 3192 participantsVery low
Summary of findings table ‐ Any psychosocial intervention vs treatment
Number of continuously abstinent women ‐ total · stopping or reducing alcohol consumption during pregnancy
Psychosocial and medication interventions to stop or reduce alcohol consumption during pregnancy (2024) · Cochrane
RR 1.34 [1.14, 1.57]3 studies · 378 participantsLow
Summary of findings table ‐ Any psychosocial intervention vs treatment
Number of drinks per day ‐ total · stopping or reducing alcohol consumption during pregnancy
Psychosocial and medication interventions to stop or reduce alcohol consumption during pregnancy (2024) · Cochrane
no estimate extracted2 studies · 157 participantsVery low
Summary of findings table ‐ Any psychosocial intervention vs treatment
Number of women who completed treatment ‐ total · stopping or reducing alcohol consumption during pregnancy
Psychosocial and medication interventions to stop or reduce alcohol consumption during pregnancy (2024) · Cochrane
RR 0.98 [0.94, 1.02]7 studies · 1283 participantsModerate
Summary of findings table ‐ Any psychosocial intervention vs treatment
Adverse events ‐ not measured · stopping or reducing alcohol consumption during pregnancy
Psychosocial and medication interventions to stop or reduce alcohol consumption during pregnancy (2024) · Cochrane
no estimate extractedNRNo studies
Summary of findings table ‐ Any psychosocial intervention vs treatment
Withdrawal signs and symptoms ‐ not measured · stopping or reducing alcohol consumption during pregnancy
Psychosocial and medication interventions to stop or reduce alcohol consumption during pregnancy (2024) · Cochrane
no estimate extractedNRNo studies
Effects of instructions vs no instructions
PAR (dB) at short‐term · workers exposed to noise using earplugs
Hearing protection field attenuation estimation systems and associated training for reducing workers’… (2024) · Cochrane
no estimate extracted1 study · 285 participantsModerate
Effects of extensive instructions vs simple instructions
Proportion of workers who wear HPDs · workers exposed to noise using HPDs
Hearing protection field attenuation estimation systems and associated training for reducing workers’… (2024) · Cochrane
no estimate extractedNRNo studies
Effects of instructions vs no instructions
PAR (dB) at long‐term · workers exposed to noise using earplugs
Hearing protection field attenuation estimation systems and associated training for reducing workers’… (2024) · Cochrane
no estimate extracted1 study · 103 participantsModerate
Effects of instructions vs no instructions
PAR (dB) at immediate · workers exposed to noise using earplugs
Hearing protection field attenuation estimation systems and associated training for reducing workers’… (2024) · Cochrane
no estimate extracted1 study · 100 participantsLow
Effects of instructions vs no instructions
PAR pass rate (%) · workers exposed to noise using earplugs
Hearing protection field attenuation estimation systems and associated training for reducing workers’… (2024) · Cochrane
no estimate extractedNRNo studies
Effects of instructions vs no instructions
Adverse effects · workers exposed to noise using earplugs
Hearing protection field attenuation estimation systems and associated training for reducing workers’… (2024) · Cochrane
no estimate extractedNRNo studies
Effects of instructions vs no instructions
Proportion of workers who wear HPDs · workers exposed to noise using earplugs
Hearing protection field attenuation estimation systems and associated training for reducing workers’… (2024) · Cochrane
no estimate extractedNRNo studies
Effects of extensive instructions vs simple instructions
PAR (dB) ‐ Fit testing of foam earplugs (immediate) · workers exposed to noise using HPDs
Hearing protection field attenuation estimation systems and associated training for reducing workers’… (2024) · Cochrane
no estimate extracted1 study · 321 participantsModerate
Effects of extensive instructions vs simple instructions
PAR pass rate (%) ‐ Fit testing of foam earplugs (immediate) · workers exposed to noise using HPDs
Hearing protection field attenuation estimation systems and associated training for reducing workers’… (2024) · Cochrane
RR 1.75 [1.44, 2.11]1 study · 321 participantsModerate
Effects of extensive instructions vs simple instructions
Adverse effects · workers exposed to noise using HPDs
Hearing protection field attenuation estimation systems and associated training for reducing workers’… (2024) · Cochrane
no estimate extractedNRNo studies
Transcranial direct current stimulation (tDCS) vs sham tDCS
Word retrieval · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extractedNRNo studies
Active tDCS plus semantic and phonological word‐retrieval training vs sham tDCS plus semantic and phonological word‐retrieval training
Adverse events · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extracted2 studies · 37 participantsVery low
Active tDCS plus phonological word‐retrieval training vs sham tDCS plus phonological word‐retrieval training
Word retrieval · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extracted1 study · 6 participantsVery low
Active tDCS plus phonological word‐retrieval training vs sham tDCS plus phonological word‐retrieval training
Overall language abilities · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extractedNRNo studies
Active tDCS plus phonological word‐retrieval training vs sham tDCS plus phonological word‐retrieval training
Overall cognitive assessment · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extractedNRNo studies
Active tDCS plus phonological word‐retrieval training vs sham tDCS plus phonological word‐retrieval training
Quality of life · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extractedNRNo studies
Active tDCS plus phonological word‐retrieval training vs sham tDCS plus phonological word‐retrieval training
Adverse events · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extracted1 study · 6 participantsVery low
Active tDCS plus semantic word‐retrieval training vs sham tDCS plus semantic word‐retrieval training
Word retrieval · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extracted1 study · 3 participantsVery low
Active tDCS plus semantic word‐retrieval training vs sham tDCS plus semantic word‐retrieval training
Overall language abilities · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extractedNRNo studies
Active tDCS plus semantic word‐retrieval training vs sham tDCS plus semantic word‐retrieval training
Overall cognitive assessment · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extractedNRNo studies
Active tDCS plus semantic word‐retrieval training vs sham tDCS plus semantic word‐retrieval training
Quality of life · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extractedNRNo studies
Transcranial direct current stimulation (tDCS) vs sham tDCS
Overall language abilities · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extracted1 study · 15 participantsVery low
Active tDCS plus semantic word‐retrieval training vs sham tDCS plus semantic word‐retrieval training
Adverse events · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extracted1 study · 3 participantsVery low
Repetitive transcranial magnetic stimulation (rTMS) vs active control‐site rTMS
Word retrieval · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extractedNRNo studies
Repetitive transcranial magnetic stimulation (rTMS) vs active control‐site rTMS
Overall language abilities · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extracted1 study · 27 participantsVery low
Repetitive transcranial magnetic stimulation (rTMS) vs active control‐site rTMS
Overall cognitive assessment · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extracted1 study · 27 participantsVery low
Repetitive transcranial magnetic stimulation (rTMS) vs active control‐site rTMS
Quality of life · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extractedNRNo studies
Repetitive transcranial magnetic stimulation (rTMS) vs active control‐site rTMS
Adverse events · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extracted1 study · 27 participantsVery low
Transcranial direct current stimulation (tDCS) vs sham tDCS
Overall cognitive assessment · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extractedNRNo studies
Transcranial direct current stimulation (tDCS) vs sham tDCS
Quality of life · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extractedNRNo studies
Transcranial direct current stimulation (tDCS) vs sham tDCS
Adverse events · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extracted1 study · 15 participantsVery low
Active tDCS plus semantic and phonological word‐retrieval training vs sham tDCS plus semantic and phonological word‐retrieval training
Word retrieval · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extracted4 studies · 93 participantsVery low
Active tDCS plus semantic and phonological word‐retrieval training vs sham tDCS plus semantic and phonological word‐retrieval training
Overall language abilities · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extracted2 studies · 28 participantsVery low
Active tDCS plus semantic and phonological word‐retrieval training vs sham tDCS plus semantic and phonological word‐retrieval training
Overall cognitive assessment · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extracted2 studies · 37 participantsVery low
Active tDCS plus semantic and phonological word‐retrieval training vs sham tDCS plus semantic and phonological word‐retrieval training
Quality of life · adults with primary progressive aphasia (PPA)
Non‐pharmacological interventions for improving language and communication in people with primary… (2024) · Cochrane
no estimate extracted1 study · 16 participantsVery low
Prebiotics vs placebo
Clinical remission (14 days) · people with mild‐to‐moderate disease (Rachmilewitz index) or active disease (SCCAI score of 4 to 10)
Prebiotics for induction and maintenance of remission in ulcerative colitis (2024) · Cochrane
RR 1.05 [0.57, 1.94]1 study · 19 participantsVery low
Inulin and oligofructose 15 g vs inulin and oligofructose 7.5 g daily
Withdrawals due to adverse events (9 weeks) · people with mild to moderately active ulcerative colitis
Prebiotics for induction and maintenance of remission in ulcerative colitis (2024) · Cochrane
RR 0.53 [0.11, 2.5]1 study · 31 participantsVery low
Prebiotics and anti‐inflammatory therapy vs anti‐inflammatory therapy
Clinical remission · people with mild‐to‐moderate ulcerative colitis based on Truelove and Witts criteria
Prebiotics for induction and maintenance of remission in ulcerative colitis (2024) · Cochrane
no estimate extractedNRNo studies
Prebiotics and anti‐inflammatory therapy vs anti‐inflammatory therapy
Clinical improvement (Lichtiger index) (4 weeks) · people with mild‐to‐moderate ulcerative colitis based on Truelove and Witts criteria
Prebiotics for induction and maintenance of remission in ulcerative colitis (2024) · Cochrane
no estimate extracted1 study · 18 participantsVery low
Prebiotics and anti‐inflammatory therapy vs anti‐inflammatory therapy
Quality of life · people with mild‐to‐moderate ulcerative colitis based on Truelove and Witts criteria
Prebiotics for induction and maintenance of remission in ulcerative colitis (2024) · Cochrane
no estimate extractedNRNo studies
Prebiotics and anti‐inflammatory therapy vs anti‐inflammatory therapy
Total adverse events · people with mild‐to‐moderate ulcerative colitis based on Truelove and Witts criteria
Prebiotics for induction and maintenance of remission in ulcerative colitis (2024) · Cochrane
no estimate extractedNRNo studies