Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

374 questions · 377 findings · 63 reviews · Pregnancy and Childbirth

No studies found 88 · 23.3%GRADE not reported 32 · 8.5%Very low 92 · 24.4%Low 103 · 27.3%Moderate 50 · 13.3%High 12 · 3.2%

Discontinued intravenous (IV) oxytocin stimulation vs continued IV oxytocin stimulation

Apgar score less than 7 at 5 minutes · pregnant women in latent phase of labour stimulated with oxytocin for with induction of labour. No exclusion criteria were applied in…

Discontinued intravenous (IV) oxytocin stimulation may leads to lower apgar score at five minutes below seven compared with continued IV oxytocin stimulation (low certainty).

1 finding from 1 review

Outcomes for all interventions for smoking cessation in pregnancy vs control: subgrouped by main intervention strategy (comparison 20)

Birthweight < 2500 (g) · Pregnant women who smoke

Outcomes for all interventions for smoking cessation in pregnancy leads to lower low birthweight (under 2500 g) compared with control: subgrouped by main intervention strategy (comparison 20) (high certainty).

1 finding from 1 review

Admission cardiotocography vs intermittent auscultation

Rate of caesarean section · Low risk pregnant women. All of the women were in labour.

Admission cardiotocography showed no clear difference in incidence of caesarean section compared with intermittent auscultation (low‐risk women) (moderate certainty).

1 finding from 1 review

Admission cardiotocography vs intermittent auscultation

Instrumental vaginal birth · Low risk pregnant women. All of the women were in labour.

Admission cardiotocography showed no clear difference in incidence of operative vaginal birth compared with intermittent auscultation (low‐risk women) (low certainty).

1 finding from 1 review

Admission cardiotocography vs intermittent auscultation

Perinatal mortality rate (fetal and neonatal deaths excluding lethal congenital anomalies) · Low risk pregnant women. All of the women were in labour.

Admission cardiotocography showed no clear difference in perinatal mortality rate (fetal and neonatal deaths excluding lethal… compared with intermittent auscultation (low‐risk women) (moderate certainty).

1 finding from 1 review

Admission cardiotocography vs intermittent auscultation

Incidence of continuous electronic fetal monitoring during labour · Low risk pregnant women. All of the women were in labour.

Admission cardiotocography may leads to higher incidence of continuous electronic fetal monitoring during labour compared with intermittent auscultation (low‐risk women) (low certainty).

1 finding from 1 review

Admission cardiotocography vs intermittent auscultation

Incidence and severity of hypoxic ischaemic encephalopathy (incidence only reported) · Low risk pregnant women. All of the women were in labour.

It is very uncertain whether admission cardiotocography changes incidence and severity of hypoxic ischaemic encephalopathy… compared with intermittent auscultation (low‐risk women) (very low certainty).

1 finding from 1 review

Admission cardiotocography vs intermittent auscultation

Neonatal seizures · Low risk pregnant women. All of the women were in labour.

Admission cardiotocography showed no clear difference in incidence of seizures in the neonatal period compared with intermittent auscultation (low‐risk women) (low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Low birthweight · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in low birthweight compared with same supplement without iodine or no treatment/placebo (child… (low certainty).

1 finding from 1 review

Intervention not reported

Low birthweight (less than 2500 g) ‐ assuming independence between twins/triplets · women with multiple pregnancy

The intervention showed no clear difference in low birthweight (less than 2500 g) ‐ assuming independence between… (low certainty).

1 finding from 1 review

Intervention not reported

Perinatal/neonatal death or severe neonatal morbidity ‐ Low national perinatal mortality rate · women with term breech delivery

The intervention probably leads to lower perinatal/neonatal death or severe neonatal morbidity ‐ Low national… (moderate certainty).

1 finding from 1 review

Single‐dose antibiotic vs short duration antibiotics

Low birthweight ‐ Same antimicrobial agent only · patients with asymptomatic bacteriuria during pregnancy

Single‐dose antibiotic leads to higher low birthweight ‐ Same antimicrobial agent only compared with short‐course (four‐ to seven‐day) antibiotic (high certainty).

1 finding from 1 review

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

Low birthweight · pregnant women

(Infant outcomes) Any supplements containing iron showed no clear difference in low birthweight (less than 2500 g) (ALL) compared with same supplements without iron or no treatment/placebo (no iron or… (low certainty).

1 finding from 1 review