Cochrane · systematic review · CD000491
Duration of treatment for asymptomatic bacteriuria during pregnancy
Widmer, M, Lopez, I, Gülmezoglu, AM, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 37.5%Low 2 · 25%Moderate 1 · 12.5%High 2 · 25%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Single‐dose antibiotic versus short‐course (four‐ to seven‐day) antibiotic for asymptomatic bacteriuria during pregnancy
Population: patients with asymptomatic bacteriuria during pregnancy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
No cure ‐ all trials Single‐dose antibiotic vs short‐course (four‐ to seven‐day) antibiotic | RR 1.28 [0.87, 1.88] | 13 studies · 1502 participants | Very low Downgraded: risk of bias, imprecision |
Recurrent asymptomatic bacteriuria ‐ all trials Single‐dose antibiotic vs short‐course (four‐ to seven‐day) antibiotic | RR 1.13 [0.77, 1.66] | 8 studies · 445 participants | Very low Downgraded: risk of bias, imprecision |
Pyelonephritis ‐ Same antimicrobial agent only4 Single‐dose antibiotic vs short‐course (four‐ to seven‐day) antibiotic | RR 3.09 [0.54, 17.55] | 2 studies · 102 participants | Very low Downgraded: risk of bias, imprecision |
Low birthweight ‐ Same antimicrobial agent only Single‐dose antibiotic vs short‐course (four‐ to seven‐day) antibiotic | RR 1.65 [1.06, 2.57] | 1 study · 714 participants | High |
Preterm delivery ‐ Same antimicrobial agent only Single‐dose antibiotic vs short‐course (four‐ to seven‐day) antibiotic | RR 1.17 [0.77, 1.78] | 3 studies · 804 participants | Moderate Downgraded: imprecision |
Side effects ‐ all trials Single‐dose antibiotic vs short‐course (four‐ to seven‐day) antibiotic | RR 0.7 [0.56, 0.88] | 12 studies · 1460 participants | Low Downgraded: risk of bias |
Single‐dose antibiotic versus short‐course (four‐ to seven‐day) antibiotic for asymptomatic bacteriuria during pregnancy (subgrouped by trial quality)
Population: patients with asymptomatic bacteriuria during pregnancy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Same antimicrobial agent ‐ No cure (good quality studies) Single‐dose antibiotic vs short‐course (four‐ to seven‐day) antibiotic | RR 1.72 [1.27, 2.33] | 2 studies · 803 participants | High |
Different antimicrobial agents ‐ No cure (good quality studies) Single‐dose antibiotic vs short‐course (four‐ to seven‐day) antibiotic | RR 1.36 [0.24, 7.75] | 1 study · 84 participants | Low Downgraded: imprecision |