Mucocele prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in mucocele between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 0.02 [0.00, 1.09]
Studies not reported
Very low
Relative abundance of Veillonella spp. · Young children with early childhood caries and caries-free controls
Veillonella spp. is more abundant in children with early childhood caries than in caries-free children (mean difference 2.22, 95% CI 0.54 to 3.90); very low certainty.
Early childhood caries (ECC) - association at lead SNP rs1044956 (7:24854765; nearest gene(s) OSBPL3, NPVF) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
The common variant rs1044956 near OSBPL3, NPVF showed suggestive (not genome-wide significant) association with ECC (Z = 4.551, p = 5.35e-6); genetic association, ungraded.
2 findings from 1 review
Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
cART was associated with a significantly lower prevalence of oral candidiasis in CLWH (very low certainty).
1 finding from 1 review
OR 0.35 [0.24, 0.51]
Studies not reported
Very low
Intervention not reported
Caries experience - % with caries (descriptive), primary dentition
1 finding from 1 review
Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
Oral candidiasis prevalence did not differ significantly between treatment-naive CLWH and those on monotherapy or dual therapy (very low certainty).
1 finding from 1 review
Purchase requests · Children and adolescents (general population, aged under 20 years)
Nonrandomized evidence on purchase requests is very uncertain (very low certainty).
2 findings from 1 review
A single observational study contributed to the combination-of-P-values analysis for purchase requests.
1 study
Very low
Combination of P values statistically significant in both model iterations, indicating evidence of an association of food marketing with purchase requests.
5 studies
Moderate
Immediate bond strength (MPa) · Glass-ionomer cement bonded to sound dentin (in vitro)
SDF pretreatment without a rinsing step does not affect glass-ionomer cement bond strength to sound dentin (MD 0.26 MPa, 95% CI -0.20 to 0.73; ungraded).
1 finding from 1 review
Dental development and maturation · Children and adolescents (<18 years) living with HIV (CLWH)
No eligible studies compared dental development and maturation between different ART regimens.
1 finding from 1 review
Food choice · Children and adolescents (general population, aged under 20 years)
Food marketing probably increases children's choice of the marketed food (OR, 1.97; moderate certainty, RCTs).
3 findings from 1 review
Angular cheilitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in angular cheilitis between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 0.58 [0.17, 1.99]
Studies not reported
Very low
Caries lesion initiation/progression (ICDAS score, laser fluorescence/DIAGNOdent, photographic pixels, enamel acid resistance) · Patients (children and adults, age 3-40 years) with initial enamel caries lesions (non-orthodontic and orthodontic)
No meta-analysis was possible for the 5 in vivo RCTs (high heterogeneity); narratively nHA showed generally no significant difference versus fluoridated dentifrice, and the evidence was not graded (ungraded).
1 finding from 1 review
Efficacy of nano-hydroxyapatite on caries prevention-a systematic review and meta-analysis. 2022 All outcomesMedian follow-up 6 months (range 6-12 months) · In vivo (clinical); non-orthodontic and orthodontic patients
No meta-analysis was performed for the in vivo studies owing to high heterogeneity (population, control group, outcomes, follow-up periods, risk of bias) and differing statistical designs (e.g., non-inferiority);…
5 studies · 420 participants
GRADE not reported
Ulcerative stomatitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
Ulcerative stomatitis was significantly more prevalent in treatment-naive CLWH than in those on ART (very low certainty).
1 finding from 1 review
OR 0.03 [0.02, 0.07]
Studies not reported
Very low
Intervention not reported
Caries experience - mean dft (descriptive), primary dentition
1 finding from 1 review
Dental caries prevalence · European adolescents aged 12–19 years
Pooled caries prevalence was 0.74 (I² = 99.9%).
1 finding from 1 review
Acute necrotizing ulcerative gingivitis/periodontitis (WHO clinical stage 3) · Children or adolescents
No eligible studies reported acute necrotizing ulcerative gingivitis/periodontitis.
1 finding from 1 review
Overweight/obesity risk · Healthy children aged 6–24 months in Western industrialized countries
BLW was associated with lower overweight/obesity risk in observational studies, but the certainty was very low.
1 finding from 1 review
Chronic herpes simplex infection (WHO clinical stage 4) · Children or adolescents
No eligible studies reported chronic herpes simplex infection.
1 finding from 1 review
Caries experience by cleft type · Children in the primary dentition with cleft lip and/or palate (CL/P)
Whether cleft type is associated with caries experience could not be determined; the planned CP-versus-CL/P subgroup analysis was not possible owing to sparse isolated-CP data (5 studies described narratively; ungraded).
1 finding from 1 review
Caries prevalence in permanent dentition · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)
A primary-dentition DMFT over 13 is associated with about 15 times higher risk of caries in permanent teeth (single study; not GRADE-rated).
1 finding from 1 review