Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,345 questions · 4,525 findings · 483 reviews

No studies found 1,024 · 22.6%GRADE not reported 388 · 8.6%Very low 1,172 · 25.9%Low 1,227 · 27.1%Moderate 576 · 12.7%High 138 · 3%

Prophylactic platelet transfusion prior to surgery vs alternative treatment

Number of participants with minor procedure‐related bleeding within 7 days of surgery · people with a low platelet count

It is very uncertain whether prophylactic platelet transfusion prior to surgery changes number of participants with minor procedure‐related bleeding within… compared with alternative treatments (very low certainty).

1 finding from 1 review

Phacoemulsification + supraciliary microstent surgery vs phacoemulsification alone

Proportion of participants who required further glaucoma surgery, including laser · people with open‐angle glaucoma

Phacoemulsification + supraciliary microstent surgery showed no clear difference in proportion of participants who required further glaucoma surgeryat… compared with phacoemulsification alone (low certainty).

1 finding from 1 review

Vaginal POP surgery with concomitant continence procedure vs no concomitant continence procedure

Vaginal POP surgery with or without concomitant continence surgery: additional MUS vs vaginal repair alone · women with POP and occult SUI

Vaginal POP surgery with concomitant continence procedure probably leads to lower vaginal POP surgery with or without concomitant continence surgery:… compared with no concomitant continence procedure (moderate certainty).

1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs no prophylactic plasma transfusion before surgery/invasive procedures (colloid, crystalloid, placebo, or no treatment)

All‐cause mortality up to 30 days № of participants: 72 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures

It is very uncertain whether prophylactic plasma transfusion before surgery/invasive procedures changes all‐cause mortality up to 30 days № of participants: 72 (1 RCT) compared with no prophylactic plasma transfusion before surgery/invasive… (very low certainty).

1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs no prophylactic plasma transfusion before surgery/invasive procedures (colloid, crystalloid, placebo, or no treatment)

Major bleeding · patients undergoing non‐cardiac surgery/invasive procedures

It is very uncertain whether prophylactic plasma transfusion before surgery/invasive procedures changes major bleeding within 24 hours № of participants: 148 (2 RCTs) compared with no prophylactic plasma transfusion before surgery/invasive… (very low certainty).

1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs no prophylactic plasma transfusion before surgery/invasive procedures (colloid, crystalloid, placebo, or no treatment)

Number of transfusions per participant within 7 days ‐ not reported · patients undergoing non‐cardiac surgery/invasive procedures
1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs no prophylactic plasma transfusion before surgery/invasive procedures (colloid, crystalloid, placebo, or no treatment)

Number of individuals requiring a transfusion within 7 days № of participants: 60 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures

It is very uncertain whether prophylactic plasma transfusion before surgery/invasive procedures changes number of individuals requiring a transfusion within 7 days № of… compared with no prophylactic plasma transfusion before surgery/invasive… (very low certainty).

1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs no prophylactic plasma transfusion before surgery/invasive procedures (colloid, crystalloid, placebo, or no treatment)

Serious adverse events measured by plasma transfusion‐related complications within 24 hours № of participants: 21 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures
1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs no prophylactic plasma transfusion before surgery/invasive procedures (colloid, crystalloid, placebo, or no treatment)

Quality of life ‐ not reported · patients undergoing non‐cardiac surgery/invasive procedures

The review found no eligible studies for this question.

1 finding from 1 review

Vaginal or abdominal POP surgery with concomitant continence procedure vs no concomitant continence procedure

Vaginal POP surgery with or without concomitant continence surgery: additional MUS vs vaginal repair alone · continent women with POP

Vaginal or abdominal POP surgery with concomitant continence procedure showed no clear difference in vaginal POP surgery with or without concomitant continence surgery:… compared with no concomitant continence procedure (moderate certainty).

1 finding from 1 review

Vaginal or abdominal POP surgery with concomitant continence procedure vs no concomitant continence procedure

Abdominal POP surgery with or without concomitant continence surgery: additional Burch colposuspension vs sacrocolpopexy alone · continent women with POP

Vaginal or abdominal POP surgery with concomitant continence procedure showed no clear difference in abdominal POP surgery with or without concomitant continence… compared with no concomitant continence procedure (low certainty).

1 finding from 1 review

Endoscopic surgery vs open surgery

Resolution of symptoms · patients with trigger finger

It is very uncertain whether endoscopic surgery changes resolution of symptoms compared with open surgery (very low certainty).

1 finding from 1 review

Endoscopic surgery vs open surgery

Participant global assessment of success Not measured · patients with trigger finger

The review found no eligible studies for this question.

1 finding from 1 review