Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

158 questions · 175 findings · 31 reviews · Headline outcomes only

No studies found 41 · 23.4%GRADE not reported 0 · 0%Very low 48 · 27.4%Low 63 · 36%Moderate 20 · 11.4%High 3 · 1.7%

Intervention not reported

Analgesia duration 1 mg morphine vs 4 mg/5 mg morphinetime duration from the end of surgery to the first time of analgesic consumption · patients undergoing knee arthroscopy
1 finding from 1 review

Intervention not reported

Adverse events 1 mg morphine vs 4 mg/5 mg morphinePercentage of participants with any adverse event · patients undergoing knee arthroscopy

The review found no eligible studies for this question.

1 finding from 1 review

Combination of lidocaine intraperitoneal instillation plus intramuscular morphine vs lidocaine intraperitoneal instillation alone

Number of women requiring rescue medication · women undergoing PPTL under local anaesthesia

Combination of lidocaine intraperitoneal instillation plus… showed no clear difference in number of women requiring rescue medication compared with lidocaine intraperitoneal instillation alone (low certainty).

1 finding from 1 review

Combination of lidocaine intraperitoneal instillation plus intramuscular morphine vs placebo

Number of women requiring rescue medication · women undergoing PPTL under local anaesthesia

Combination of intraperitoneal lidocaine instillation and… may leads to lower number of women requiring rescue medication compared with placebo (low certainty).

1 finding from 1 review

Cannabis‐based medicines vs placebo medication

Daily breakthrough opioid dosage (mg morphine equivalent) · adults with cancer‐related pain

Cannabis‐based medicines showed no clear difference in daily breakthrough opioid dosage (mg morphine equivalent) compared with placebo medication (moderate certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Prevalence of morphine use · adult patients with substance dependence

It is very uncertain whether primary health professional‐ and community professional‐led… changes prevalence of morphine use compared with enhanced usual care (very low certainty).

1 finding from 1 review