Findings

What do systematic reviews say?

168 questions · 185 findings · 32 reviews

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No studies found 41 · 22.2%GRADE not reported 10 · 5.4%Very low 48 · 25.9%Low 63 · 34.1%Moderate 20 · 10.8%High 3 · 1.6%

Morphine vs diamorphine

Pain (PIPP) · neonates with mechanical ventilation

The review found no eligible studies for this question.

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Morphine vs diamorphine

Duration of mechanical ventilation · neonates with mechanical ventilation

The review found no eligible studies for this question.

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Morphine vs diamorphine

Neonatal mortality · neonates with mechanical ventilation

It is very uncertain whether morphine changes neonatal mortality compared with diamorphine (very low certainty).

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
RR 1.17 [0.43, 3.19]
1 study · 88 participants
Very low

Morphine vs diamorphine

Mortality before hospital discharge · neonates with mechanical ventilation

The review found no eligible studies for this question.

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Morphine vs diamorphine

Neurodevelopmental outcomes · neonates with mechanical ventilation

The review found no eligible studies for this question.

3 findings from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

IA morphine vs IM morphine

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients undergoing knee arthroscopy

3 findings from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 72 participants
Very low
Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 72 participants
Low
Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 39 participants
Low

IA morphine vs IM morphine

Analgesia durationTime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. · patients undergoing knee arthroscopy

The review found no eligible studies for this question.

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

IA morphine vs IM morphine

Adverse eventsPercentage of participants with any adverse event · patients undergoing knee arthroscopy

The review found no eligible studies for this question.

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Morphine vs placebo

Reported outcomes approximating to 30% reduction in pain · adults with neuropathic pain

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
62 participants
Very low

Morphine vs placebo

At least 50% reduction in pain · adults with neuropathic pain

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
62 participants
Very low

Morphine vs placebo

Patient Global Impression of Change much or very much improved · adults with neuropathic pain

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 32 participants
Very low

Morphine vs placebo

Any pain‐related outcome (moderate pain improvement) · adults with neuropathic pain

It is very uncertain whether morphine changes any pain‐related outcome (moderate pain improvement) compared with placebo (very low certainty).

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
RD 0.27 [0.16, 0.38]
4 studies · 263 participants
Very low

Morphine vs placebo

Serious adverse events · adults with neuropathic pain

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 289 participants
Very low

Morphine vs placebo

Death · adults with neuropathic pain

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 289 participants
Very low

Morphine vs placebo

Any adverse event · adults with neuropathic pain

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 289 participants
Very low

Morphine vs placebo

Withdrawal (all‐cause) · adults with neuropathic pain

It is very uncertain whether morphine changes all‐cause withdrawal compared with placebo (very low certainty).

1 finding from 1 review

Morphine for chronic neuropathic pain in adults 2017 · Cochrane Headline outcomes only
RD 0.04
4 studies · 289 participants
Very low

Morphine vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients undergoing knee arthroscopy

3 findings from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 297 participants
Low
Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 297 participants
Low
Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 297 participants
Low

Morphine vs bupivacaine

Adverse eventsPercentage of participants with any adverse event · patients undergoing knee arthroscopy

Morphine showed no clear difference in adverse eventsPercentage of participants with any adverse event compared with bupivacaine (moderate certainty).

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
RR 0.68 [0.09, 5.17]
4 studies · 210 participants
Moderate

Morphine vs NSAIDs

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients undergoing knee arthroscopy

3 findings from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 80 participants
Very low
Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 80 participants
Low
Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 80 participants
Low

Morphine vs NSAIDs

Analgesia durationTime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. · patients undergoing knee arthroscopy

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low