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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Every word you type has to appear somewhere in the question, and the closest matches are ranked first.
10,375 questions in 429 reviews · Oral Health
current versionsNo studies 1,344 · 13%Ungraded 6,832 · 65.9%Very low 1,228 · 11.8%Low 613 · 5.9%Moderate 290 · 2.8%High 68 · 0.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Multivariable caries prediction model vs Additional prediction model(s) Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Sánchez-Pérez,2009 [20]; model performance 1 Multivariable prediction models of caries increment: a systematic review and critical appraisal. (2023) | LR+ 3.85 [2.04, 7.27] | 1 study | Ungraded |
Multivariable caries prediction model vs Additional prediction model(s) Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Disney,1992 [15]; model performance 3 Multivariable prediction models of caries increment: a systematic review and critical appraisal. (2023) | LR+ 3.26 [2.73, 3.91] | 1 study | Ungraded |
Multivariable caries prediction model vs Additional prediction model(s) Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Fontana,2011 [16]; model performance 1 Multivariable prediction models of caries increment: a systematic review and critical appraisal. (2023) | LR− 0.34 [0.26, 0.46] | 1 study | Ungraded |
Multivariable caries prediction model vs Additional prediction model(s) Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Fontana,2011 [16]; model performance 10 Multivariable prediction models of caries increment: a systematic review and critical appraisal. (2023) | LR− 0.27 [0.19, 0.39] | 1 study | Ungraded |
Indirect restorations (crowns, fixed partial dentures, inlays/onlays/veneers) vs None (single-group incidence) Pulp necrosis · Vital teeth restored with indirect restorations · Follow-up ≤5 to >10 years, Eugenol-free temporary cement Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations:… (2023) | Proportion 5.77 [3.72, 8.24] | 639 participants | Ungraded |
Toothache / dental pain vs No dental pain Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years) Oral-health-related quality of life in adolescents: umbrella review. (2023) | Toothache, DMT and tooth loss have a high impact on OHRQoL in adolescentes [26]. There is low evidence that dental pain has a negative impact on OHRQoL [37]. | NR | Ungraded |
Periodontal disease (periodontitis; clinical attachment loss >=4 mm) vs Adults without periodontal disease (healthy periodontal status; CAL <=3 mm) Root caries (presence of root caries) · Adults (mean age ~53 years) Is there an association between periodontal disease and root caries? A systematic review and meta-analysis. (2023) | OR 1.38 [1.25, 1.53] | 2 studies · 7664 participants | Low |
38% SDF one-time application without brushing programme vs no treatment without brushing programme new carious lesions or fillings · schoolchildren with caries in permanent first molars · 18 months A systematic review on the effect of silver diamine fluoride for management of dental caries in permanent… (2023) | Mean new caries increment (surfaces) 0.12 | 1 study · 1016 participants | Ungraded |
Multivariable caries prediction model vs Additional prediction model(s) Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Dolic,2020 [28]; model performance 2 Multivariable prediction models of caries increment: a systematic review and critical appraisal. (2023) | LR+ 1.93 [1.21, 3.09] | 1 study | Ungraded |
Multivariable caries prediction model vs Additional prediction model(s) Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Fontana,2011 [16]; model performance 2 Multivariable prediction models of caries increment: a systematic review and critical appraisal. (2023) | LR+ 1.93 [1.59, 2.34] | 1 study | Ungraded |
Multivariable caries prediction model vs Additional prediction model(s) Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Hänsel Petersson,2015 [30]; model performance 4 Multivariable prediction models of caries increment: a systematic review and critical appraisal. (2023) | LR+ 2.29 [1.48, 3.55] | 1 study | Ungraded |
Light vibrational forces (LVF) vs Conventional orthodontic appliance treatment (placebo or no adjunct) Duration of orthodontic treatment · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic… (2023) · Cochrane | MD -0.61 [-2.44, 1.22] | 2 studies · 77 participants | Low |
Multivariable caries prediction model vs Additional prediction model(s) Root caries increment · Individuals of all ages · Follow-up ≥1 year, Ritter,2016 [22]; model performance 4 Multivariable prediction models of caries increment: a systematic review and critical appraisal. (2023) | LR− 0.42 [0.28, 0.64] | 1 study | Ungraded |
Multivariable caries prediction model vs Additional prediction model(s) Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Birpou,2019 [25]; model performance 3 Multivariable prediction models of caries increment: a systematic review and critical appraisal. (2023) | LR+ 1.52 [1.11, 2.09] | 1 study | Ungraded |
Access to dental care / health services vs No / limited access to dental care Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years) Oral-health-related quality of life in adolescents: umbrella review. (2023) | having parents who can provide dental care and safe housing are positive predictors for OHRQoL. access to dental care and the performance of health promotion programs are directly proportional to OHRQoL in adolescents. | NR | Ungraded |
Superselective neck dissection vs Selective neck dissection Recurrence · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment (2023) · Cochrane | Recurrence: outcome not reported in a usable way in either study. | 0 studies | No studies |
Treatment of traumatic dental injury vs No treatment of traumatic dental injury Oral health-related quality of life · Adolescents aged 10-19 years Oral-health-related quality of life in adolescents: umbrella review. (2023) | no estimate extracted | NR | Ungraded |
Glass ionomer cement (GIC) vs Resin composite (RC) Secondary caries (occurrence) · Patients requiring dental restoration; permanent teeth · 2 or more years of follow-up Clinical efficacy of bioactive restorative materials in controlling secondary caries: a systematic review… (2023) | RR 0.50 [0.28, 0.91] | 14 studies · 1571 participants | Moderate |
Multivariable caries prediction model vs Additional prediction model(s) Root caries increment · Individuals of all ages · Follow-up ≥1 year, Sánchez-García,2011 [23]; model performance 1 Multivariable prediction models of caries increment: a systematic review and critical appraisal. (2023) | LR+ 7.09 [3.29, 15.30] | 1 study | Ungraded |
Multivariable caries prediction model vs Additional prediction model(s) Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Birpou,2019 [25]; model performance 12 Multivariable prediction models of caries increment: a systematic review and critical appraisal. (2023) | LR+ 1.60 [1.15, 2.22] | 1 study | Ungraded |
Multivariable prediction model of caries increment (>=3 predictors), e.g. logistic-regression or algorithm-based caries-risk models vs Alternative prediction model(s) within the same study, or no formal comparator (models compared descriptively; no between-model statistical test) Predictive performance for coronal caries increment (positive likelihood ratio, LR+) · Children and adolescents (aged 2-19) at risk of coronal caries increment (caries onset or progression) · Follow-up >=1 year (included studies 1-5 years), Model development studies Multivariable prediction models of caries increment: a systematic review and critical appraisal. (2023) | No meta-analysis (heterogeneity precluded pooling); performance given per model as LR+ recalculated by the review authors (Table 2). Across the 8 development studies (23 coronal models) LR+ spanned roughly 1.31-10.26… | 8 studies | Ungraded |
Light vibrational forces (LVF) vs Conventional orthodontic appliance treatment (placebo or no adjunct) Total number of orthodontic appliance adjustment appointments during treatment · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic… (2023) · Cochrane | MD -0.32 [-1.69, 1.05] | 2 studies · 77 participants | Low |
Full-time wear of removable retainer (any type) vs Part-time wear of removable retainer (any type) Stability: Little's Irregularity Index (lower arch) · People who had received fixed appliance orthodontic treatment · 12 months, lower arch Retention procedures for stabilising tooth position after treatment with orthodontic braces (2023) · Cochrane | MD 0.20 [-0.28, 0.68] | 1 study · 52 participants | Very low |
Multivariable caries prediction model vs Additional prediction model(s) Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Hänsel Petersson,2010 [31]; model performance 2 Multivariable prediction models of caries increment: a systematic review and critical appraisal. (2023) | LR− 0.34 [0.22, 0.52] | 1 study | Ungraded |
Multivariable caries prediction model vs Additional prediction model(s) Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Gao,2013 [29]; model performance 9 Multivariable prediction models of caries increment: a systematic review and critical appraisal. (2023) | LR− 0.21 [0.13, 0.35] | 1 study | Ungraded |
Multivariable caries prediction model vs Additional prediction model(s) Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Gao,2013 [29]; model performance 7 Multivariable prediction models of caries increment: a systematic review and critical appraisal. (2023) | LR+ 1.04 [1.01, 1.08] | 1 study | Ungraded |
Supraomohyoid neck dissection vs Modified radical neck dissection Adverse events associated with treatment · Adults with oral cavity or oropharyngeal cancer Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment (2023) · Cochrane | Adverse events: significant difference in complication rates, lower for supraomohyoid (SOND 13.0% vs MRND 21.9%, P=0.040). UW-QOL at 1 year: supraomohyoid superior in pain relief (78.8% vs 75.2%, P=0.013) and shoulder… | 1 study · 332 participants | Very low |
Carious dentin before cavity sealing vs Carious dentin after cavity sealing MMP-2 expression/activity · Human ex vivo carious dentin under sealed cavities · Before vs after sealing (Kuhn 2016: 60 days follow-up) Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex… (2023) | There is no difference of MMP-2 expression/activity before and after cavity sealing, although the evidence is very uncertain. | 2 studies · 48 participants | Very low |
Malocclusion vs No malocclusion Oral health-related quality of life (OHRQoL), impaired (qualitative synthesis) · Adolescents aged 10-19 years Malocclusions and quality of life among adolescents: a systematic review and meta-analysis. (2023) | Impaired OHRQoL, qualitative synthesis: relative effect not estimable across the 13 studies (13,864 participants); moderate quality of evidence (GRADE). | 13 studies · 13864 participants | Moderate |
Amalgam (AAG) vs Resin-modified glass ionomer cement (RMGIC) Secondary caries (occurrence) · Patients requiring dental restoration; deciduous (primary) teeth · 2 or more years of follow-up Clinical efficacy of bioactive restorative materials in controlling secondary caries: a systematic review… (2023) | RR 2.46 [1.42, 4.27] | 8 studies · 1135 participants | Moderate |
Irradiated carious dentin vs Non-irradiated carious dentin MMP-20 expression/activity · Human ex vivo carious dentin (head/neck radiotherapy) Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex… (2023) | There is no difference about the MMP-20 expression in irradiated vs. non-irradiated carious dentin, but the evidence is very uncertain (Gomes-Silva et al., 2017b). | 1 study · 36 participants | Very low |
PET-CT following chemoradiotherapy (neck dissection only if no/incomplete response) vs Planned neck dissection before or after chemoradiotherapy Locoregional recurrence · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3) · 3 years Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment (2023) · Cochrane | HR 1.00 [0.94, 1.06] | 1 study · 564 participants | Moderate |
Multivariable caries prediction model vs Additional prediction model(s) Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Birpou,2019 [25]; model performance 10 Multivariable prediction models of caries increment: a systematic review and critical appraisal. (2023) | LR+ 1.63 [1.17, 2.26] | 1 study | Ungraded |
Elective neck dissection (at time of primary tumour resection) vs Therapeutic (delayed) neck dissection Locoregional recurrence · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes · 3 years Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment (2023) · Cochrane | HR 0.58 [0.43, 0.78] | 4 studies · 458 participants | Moderate |
Full-time clear plastic (removable) retainer vs Any type of fixed (bonded) retainer Adverse effects on oral health: gingival bleeding (lower arch) · People who had received fixed appliance orthodontic treatment · 12 months, lower arch Retention procedures for stabilising tooth position after treatment with orthodontic braces (2023) · Cochrane | RR 0.53 [0.31, 0.88] | 1 study · 84 participants | Very low |
Intervention NR New active carious lesions (permanent first molars) · Llodra 2005 (6-monthly SDF, Cuba) A systematic review on the effect of silver diamine fluoride for management of dental caries in permanent… (2023) | Mean new active carious lesions per child 0.4 vs 1.1 | 1 study | Ungraded |
Herbal mouthwash vs Blank control Plaque-related index · Orthodontic patients · ≤ 3 months The efficacy of mouthwashes on oral microorganisms and gingivitis in patients undergoing orthodontic… (2023) | PI was significantly reduced compared to baseline [39; 48; 54; 58]; BBPI was significantly reduced compared to blank control [47]; TI and dental plaque amount were significantly reduced compared to baseline [45; 38]. | 8 studies | Very low |
Intervention NR Pulp necrosis · Compound impression material Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations:… (2023) | Proportion 3.27 | 1 study | Ungraded |
Supraomohyoid neck dissection vs Modified radical neck dissection Total mortality · Adults with oral cavity or oropharyngeal cancer Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment (2023) · Cochrane | Total mortality: reported but not usable (Guo 2014: during follow-up 113/322 (35.1%) died; SOND 53, MRND 60). No GRADE rating. | 1 study | Ungraded |
Indirect restorations (crowns, fixed partial dentures, inlays/onlays/veneers) vs None (single-group incidence) Periapical pathosis · Vital teeth restored with indirect restorations · ≤5 years, Follow-up ≤5 years Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations:… (2023) | Proportion 2.26 [0.59, 4.98] | 856 participants | Ungraded |
Multivariable caries prediction model vs Additional prediction model(s) Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Birpou,2019 [25]; model performance 6 Multivariable prediction models of caries increment: a systematic review and critical appraisal. (2023) | LR− 0.54 [0.38, 0.76] | 1 study | Ungraded |
Giomer (GIONOMER) vs Resin-modified glass ionomer cement (RMGIC) Secondary caries (occurrence) · Patients requiring dental restoration; deciduous (primary) teeth · 2 or more years of follow-up Clinical efficacy of bioactive restorative materials in controlling secondary caries: a systematic review… (2023) | RR 1.66 [0.49, 5.61] | 1 study · 38 participants | Low |
Enamel pre-treatment with CPP-ACP before bonding metallic orthodontic brackets vs No enamel pre-treatment before bonding, or treatment with another material Shear bond strength (SBS) of metallic orthodontic brackets · Extracted permanent human teeth (enamel); sound or demineralized · Before bonding Shear bond strength of metallic brackets bonded to enamel pretreated with CPP-ACP: a systematic review and… (2023) | MD 1.163 [-0.321, 2.648] | 15 studies · 1379 participants | Ungraded |
Elective radical (comprehensive) neck dissection vs Elective selective neck dissection Recurrence · Adults with oral cavity cancer · 5 years Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment (2023) · Cochrane | RR 1.21 [0.63, 2.33] | 1 study · 143 participants | Very low |
Indirect restorations (crowns, fixed partial dentures, inlays/onlays/veneers) vs None (single-group incidence) Pulp necrosis · Vital teeth restored with indirect restorations · Follow-up ≤5 to >10 years, Treated by undergraduate students Incidence and influential factors in pulp necrosis and periapical pathosis following indirect restorations:… (2023) | Proportion 5.68 [3.17, 8.86] | 1604 participants | Ungraded |
Multivariable caries prediction model vs Additional prediction model(s) Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Birpou,2019 [25]; model performance 9 Multivariable prediction models of caries increment: a systematic review and critical appraisal. (2023) | LR− 0.59 [0.41, 0.85] | 1 study | Ungraded |
Botulinum toxin (BoNT) injection into salivary glands vs Placebo injection Adverse events (participants with >=1 adverse event) · Adults with Parkinson's disease and sialorrhea (drooling) · Approximately 1 month post-injection (one study ~1 week), BoNT type B The effectiveness and safety of botulinum toxin injections for the treatment of sialorrhea with Parkinson's… (2023) | RD 0.18 [0.04, 0.33] | 5 studies · 132 participants | Ungraded |
Multivariable caries prediction model vs Additional prediction model(s) Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Pang,2021 [19]; model performance 1 Multivariable prediction models of caries increment: a systematic review and critical appraisal. (2023) | LR+ 1.57 [1.24, 1.99] | 1 study | Ungraded |
Gum chewing (sugar-free) vs No gum chewing (control) Unstimulated whole salivary flow rate · Elderly (>60 years) and medically compromised adults with xerostomia / dry mouth · Gum chewed daily for >=2 weeks (2 to 12 weeks; multiple time points for Kim and Ozen) The effect of gum chewing on xerostomia and salivary flow rate in elderly and medically compromised… (2023) | SMD 0.44 [0.22, 0.66] | 6 studies · 291 participants | Ungraded |
Periodontal disease assessed by loss of attachment (LOA / clinical attachment loss) vs Individuals without periodontal disease (by LOA) Oral health-related quality of life (dichotomous: poor vs not) · Indian adults and elderly (police, teachers, general and institutionalised populations) Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023) | Periodontal disease (LOA) and QoL (dichotomous): two studies found a significant association (Saxena 2018, Abhishek 2016), one denied it (Nagarajappa 2015, P=0.687). Not pooled. | 3 studies | Ungraded |