Search review questions

Premolar caries detection accuracy · Dental images of human beings · Lee et al., 2018; CNN

Contribution to total daily fluoride intake · Children · Extreme fluoride in water (>1.5 mg/L)

Alpha diversity (study-level, caries vs health) · Per-study across 15 studies (log2 fold change; Figure 7B)

Physical growth / weight gain · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western… · First 2 years (up to 3-5 years)

Caries prevalence · European adolescents aged 16 years · Exact age

Dental caries measured by DMFT scores · Primary school children (aged 3-16 years) attending primary school in low- and middle-income countries (LMICs) · <2 years, Intervention duration <2 years

Dental caries · Healthy children aged 6–24 months in Western industrialized countries

Restoration failure · Children with carious primary teeth · 3 years, ART; Class I and II

Enamel caries proportion · European adolescents aged 18 years · Exact age

Plaque quantity (plaque index or plaque weight) · Adults and children (predominantly adults; one study in children), with natural dentition · End of study (last reported time point; study durations 4 days to 2 years)

Enamel caries proportion of total caries experience · European adolescents aged 12–19 years

Proximal caries detection accuracy · Dental images of human beings · Devito et al., 2008; hidden-layer perceptron with backpropagation

Caries experience (mean DMFS) · European adolescents aged 12–19 years · Examination type: partial-mouth

Oral health-related quality of life · Children with dental caries · Network estimate

Caries prevalence · 12-year-old children (permanent dentition) in Africa · Setting: Urban/rural (unspecified)

Dental caries (association with primary maternal education) · Children (deciduous and/or permanent dentition) in low- and middle-income countries · Primary education

Progression of non-cavitated enamel caries · Children with caries-free second primary molars, aged 4-8 years (dental clinic, Turkey and Spain)

Association between age and daily fluoride intake from toothpaste · Children using fluoride toothpaste (all tap-water fluoride categories) · All tap-water fluoride categories; Levy et al. [20,22,24] data excluded

Caries severity (mean DMFT) · 12-year-old children (permanent dentition) in Africa · Country: Algeria

Caries severity (mean DMFT) · 12-year-old children (permanent dentition) in Africa · Data collection period: 2000-2004

Restoration survival · Children with occlusoproximal caries in primary teeth · 2-3 years, Occlusoproximal cavities (Raggio 2013; Tedesco 2017)

Dental caries (association with middle SES) · Children (deciduous and/or permanent dentition) in low- and middle-income countries · Middle SES

Caries experience (mean DMFS) · European adolescents aged 12–19 years

Contribution to total daily fluoride intake · Children · High fluoride in water (0.78-1.5 mg/L)

Mucocele · Children and adolescents (<18 years) · Cross-sectional (case-control; single time point)

Adverse events · Children with sound primary molars, aged 2-4 years (municipal dental clinics or hospital paediatric clinics, Denmark)

Secondary caries · Patients with permanent dentition in need of restorations · 1 year, All types of cavities

Adverse events · Children who were regular dental attenders with caries-free first or second primary molars (public health service…

Immediate bond strength (MPa) · Glass-ionomer cement bonded to caries-affected dentin (in vitro) · Immediate bond strength, Caries-affected dentin (with rinsing step)

Immediate bond strength (MPa) · Glass-ionomer cement bonded to dentin (in vitro), sound or caries-affected · Immediate bond strength, Overall (all dentin conditions and rinsing protocols)

Treatment failure (annual failure rate) · Children with carious primary teeth treated by atraumatic restorative treatment (hand-instrument caries removal), no… · 12-48 months, Restorative technique (ART)

Caries severity (mean DMFT) · 12-year-old children (permanent dentition) in Africa · Data collection period: >2015

Caries experience at the surface level (dmfs/defs) · Children (mean age newborn to ~5.2 years) and their parents/carers

Alpha diversity (Shannon) · Children providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples · Children

Sensitivity for detecting enamel caries · Asymptomatic children or adults suspected of enamel caries (clinical studies); extracted teeth (in vitro studies) · Analysis 2: network meta-analysis (all studies evaluating >=2 index tests)

Dentinal caries in permanent (newly erupted) teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of… · 7-year follow-up, Dentinal caries in primary dentition

Discrimination of caries vs health (random forest ROC-AUC) · Individuals providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples; 2016 samples from 19 studies…

Retention of sealant (complete or partial retention) · Children with caries-free primary first molars (with or without caries on other teeth), aged 1-5 years (paediatric… · 6-30 months

Discomfort during treatment · Children (3-10 years) with dentine caries in primary molars · During treatment

Restoration failure · Children with carious primary teeth · 3 years, Class II

Treatment failure (annual failure rate) · Children with carious primary molars treated by pulpotomy (vital pulp therapy) · 2 years, PMC arm

Mucocele prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

Restoration failure · Children with carious primary teeth · 1 year, ART; Class I and II

Dental caries detection accuracy · Dental images of human beings · Zanella-Calzada et al., 2018; ANN

Caries prevalence · 12-year-old children (permanent dentition) in Africa

Relative abundance of Veillonella spp. · Children with early childhood caries (ECC) and caries-free children · Overall (all sample types)

Restoration failure · Children with carious primary teeth · 2 years, ART; Class I and II

Secondary caries (caries around restorations), all cavity types · Patients with permanent dentition in need of restorations (all cavity types: Black's Class I, II, V, and non-carious… · 3 years

Early childhood caries (ECC) - association at lead SNP rs1044956 (7:24854765; nearest gene(s) OSBPL3, NPVF) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5… · Cross-sectional (ECC ascertained at the last dental exam before age 6), rs1044956 (7:24854765); effect/non-effect allele A/G; MAF 0.49; direction across 5 cohorts +++++

Caries prevalence · European adolescents aged 12–19 years · Publication year: ≥ 2010