Search review questions

Restoration failure · Children with carious primary teeth · 2 years, ART; Class I and II

Caries prevalence · 12-year-old children (permanent dentition) in Africa · Country: Eritrea

Caries experience at the surface level (dmfs/defs) · Children (mean age newborn to ~5.2 years) and their parents/carers · Oral health education only (vs comprehensive intervention)

Angular cheilitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

Restoration failure · Children (3-13 years) with dentine caries in primary teeth, no pulpal involvement · 12-24 months

Proximal caries detection accuracy · Dental images of human beings · Casalegno et al., 2018; CNN

Caries development in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of… · 8-year follow-up, First and second primary molars

Caries prevalence · 12-year-old children (permanent dentition) in Africa · Country: South Africa

Caries experience · European adolescents aged 17 years · Exact age

Pulp exposure during caries removal · Children with dentine caries in primary and permanent teeth · 12 months, Primary and permanent teeth combined (2 studies)

Caries prevalence · 12-year-old children (permanent dentition) in Africa · Country: Libya

Immediate bond strength (MPa) · Glass-ionomer cement bonded to sound dentin (in vitro) · Immediate bond strength, Sound dentin (with rinsing step)

Oral health-related quality of life · Children with dental caries · Direct estimate

Occlusal caries detection accuracy · Dental images of human beings · Moutselos et al., 2019; MASK R-CNN; worst class

Caries prevalence · European adolescents aged 12–19 years · Examination type: partial-mouth

Caries arrest · Children (age 1-10 years) with active cavitated dentin caries lesions in primary molars · Follow-up up to 12 months (biannual application), SDF application frequency: biannual (every 6 months)

Restoration failure · Children with carious primary teeth · 1 year, ART; Class I, II, III, and V

Oral health-related quality of life (OHRQoL; B-ECOHIS) · Children with dental caries (ages ~2-13 years in the pooled trials) · Post-treatment

Caries prevalence in permanent dentition · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of… · 7-year follow-up, Primary DMFT 1-3

Treatment failure (annual failure rate) · Children with deep dentine caries in primary molars restored with composite resin (indirect pulp treatment; pulpotomy… · 36 months, Complete caries removal (CCR) arm

Caregiver help with tooth brushing prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries

Recurrent oral ulceration prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

Caries prevalence · European adolescents aged 16 years · Exact age

Restoration failure · Children with carious primary teeth after vital or non-vital pulp therapy · 2 years

Female sex prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries

Retention of sealant (complete or partial retention) · Children with caries-free second primary molars, aged 4-8 years (dental clinic, Turkey and Spain) · 6-24 months

Dental caries prevalence (DMFT/dmft/DMFS/dmfs > 0) · Children and adolescents (<18 years) · Cross-sectional (case-control; single time point), Permanent dentition (DMFT > 0)

Color change · Patients with post-orthodontic white spot lesions and permanent dentition · 6 months

Choking events · Healthy children aged 6–24 months in Western industrialized countries

Color change · Patients with post-orthodontic white spot lesions and permanent dentition · 6 months

Treatment failure (annual failure rate) · Children with carious primary molars treated by pulpotomy (vital pulp therapy) · 2 years, Composite resin (CR) arm

HIV-related oral lesions · Children and adolescents living with HIV on ART/HAART · Cross-sectional (case-control; single time point), CD4+ T-cell count <250 cells/mm3 vs higher

Caries experience (mean DMFS) · European adolescents aged 12–19 years · Publication year: ≥ 2010

Adverse events · Children with caries-free primary first molars (with or without caries on other teeth), aged 1-5 years (paediatric…

Type 2 diabetes (later in life) · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western… · Later in life

Marginal adaptation (unacceptable marginal adaptation) · Patients with permanent dentition in need of restorations (all cavity types: Black's Class I, II, V, and non-carious… · 3 years

Dental caries detection accuracy · Dental images of human beings · Mayank et al., 2017; F-CNN

Contribution of dental care products to total daily fluoride intake (TDFI), by tap-water fluoride level · Adults using fluoride-containing dental care products (two included studies [28,47]; aged 20-35) · Habitual daily intake, Medium-fluoridated tap water (0.52-0.77 mg/L)

Sugary drinks/sweets consumption prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries

Secondary caries (caries around restorations), all cavity types · Patients with permanent dentition in need of restorations (all cavity types: Black's Class I, II, V, and non-carious… · 18 months-2 years

Unacceptable marginal adaptation · Patients with permanent dentition in need of restorations · 3 years, All types of cavities

Caries severity (mean DMFT) · Publication-bias adjusted (trim-and-fill)

Caries prevalence · Publication-bias adjusted (trim-and-fill)

Alpha diversity (Observed, Chao1, Shannon, and Simpson) · Participants in oral 16S rRNA caries microbiome studies

Dental caries measured by DMFS scores · Primary school children (aged 3-16 years) attending primary school in low- and middle-income countries (LMICs) · Post-intervention; follow-up varied across studies (interventions ranged from <2 years to >=2 years and longer), <=3 intervention activities

Pulp exposure during caries removal · Children (3-11 years) with symptomless, vital dentine caries in primary molars · 12 months, Primary teeth

Caries experience at the surface level (dmfs/defs) · Children (mean age newborn to ~5.2 years) and their parents/carers · Comprehensive intervention (vs oral health education only)

Treatment failure (annual failure rate) · Children with Class-I carious lesions in primary molars, no pulp therapy · 18 months (Oliveira 2008), Cavity margin (bevel vs no bevel)

Food purchasing · Children and adolescents aged 0-19 years · Vote counting by direction of effect

Early childhood caries (ECC) - association at lead SNP rs563135 (10:115067899; nearest gene(s) TCF7L2, CASP7) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5… · Cross-sectional (ECC ascertained at the last dental exam before age 6), rs563135 (10:115067899); effect/non-effect allele A/C; MAF 0.51; direction across 5 cohorts -----