Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,271 questions · 1,326 findings · 329 reviews

No studies found 247 · 18.6%GRADE not reported 237 · 17.9%Very low 379 · 28.6%Low 285 · 21.5%Moderate 141 · 10.6%High 37 · 2.8%

Intermittent 'as needed' ICS vs daily ICS

Number of participants experiencing one or more episode requiring treatment with oral steroids · Children and adults with persistent asthma.

Intermittent 'as needed' ICS showed no clear difference in patients with 1 or more exacerbations requiring oral corticosteroids… compared with daily ICS (low certainty).

1 finding from 1 review

Long‐acting beta2‐agonists vs placebo

Participants with one or more serious adverse event (non‐fatal) · patients with chronic obstructive pulmonary disease

Long‐acting beta2‐agonists showed no clear difference in participants with one or more serious adverse event (non‐fatal) compared with placebo (moderate certainty).

1 finding from 1 review

Fluorescence camera (FC) vs Reference standard

More advanced caries lesion detection · Permanent teeth with occlusal surfaces

Pooled specificity was reported, but the numerical estimate is not stated in the supplied text or attached figures; I²=17%; no GRADE rating was reported.

2 findings from 1 review

A 10-minute film followed by the same 30-minute one-to-one hygienist instruction on sugar consumption and dental health, plus oral hygiene, fluoride and regular visits (a multi-intervention) vs No special instructions (control)

Mean sugar consumption (self-reported, 1 to 5 scale; higher score = more positive behaviour) · Adults newly registered at a group dental practice in a suburban Dutch village, the Netherlands
1 finding from 1 review

Brief motivational interviewing (BMI) vs usual treatment alone

Alcohol consumption: consuming more than 21 units of alcohol per week · Male patients aged 16 to 35 years attending an oral and maxillofacial surgery outpatient clinic for follow-up of an alcohol-related facial…

Brief one-session, manual-guided discussion based on the principles… led to lower alcohol consumption: consuming more than 21 units of alcohol per week compared with treatment at the outpatient clinic as usual; GRADE not reported.

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE

Global state: 2. Requiring 3 or more injections ‐ over 7 days · patients with acute schizophrenia and similar serious mental illnesses

ZUCLOPENTHIXOL ACETATE may leads to lower global state: 2. Requiring 3 or more injections ‐ over 7 days compared with STANDARD DRUG CARE (low certainty).

1 finding from 1 review

Asthma Clinics (Intervention) vs controls

Number of participants experiencing one or more episodes requiring ED visit · people with asthma

It is very uncertain whether asthma Clinics (Intervention) changes A&E visits Number of people experiencing one or more A&E visit compared with controls (very low certainty).

1 finding from 1 review

Asthma Clinics (Intervention) vs controls

Hospital admissions · people with asthma

Asthma Clinics (Intervention) showed no clear difference in hospital admissions Number of people experiencing one or more… compared with controls (low certainty).

1 finding from 1 review

Intervention not reported

Readmission to hospital, inpatient. Number of people experiencing one or more readmissions ( · exacerbations of COPD

The intervention probably leads to lower readmission to hospital, inpatient. Number of people experiencing… (moderate certainty).

1 finding from 1 review

Intervention not reported

More than 50% improvement in pure‐tone average threshold Risk ratio · patients with idiopathic sudden sensorineural hearing loss or tinnitus

The intervention showed no clear difference in more than 50% improvement in pure‐tone average threshold Risk ratio (moderate certainty).

1 finding from 1 review

Intervention not reported

More than 25% improvement in pure‐tone average threshold Risk ratio · patients with idiopathic sudden sensorineural hearing loss or tinnitus

The intervention probably leads to higher more than 25% improvement in pure‐tone average threshold Risk ratio (moderate certainty).

1 finding from 1 review

Curcumin vs placebo

Relapse at 6 months Clinical Disease Activty Index more than 42 · Maintenance of remission in ulcerative colitis

Curcumin showed no clear difference in relapse at 6 months Clinical Disease Activty Index more than 42 compared with placebo (low certainty).

1 finding from 1 review

Curcumin vs placebo

Relapse at 12 months Clinical Disease Activty Index more than 42 · Maintenance of remission in ulcerative colitis

Curcumin showed no clear difference in relapse at 12 months Clinical Disease Activty Index more than 42 compared with placebo (low certainty).

1 finding from 1 review

Tiotropium vs long‐acting beta‐agonists

Hospitalisations, number of participants with 1 or more exacerbations · patients with stable chronic obstructive pulmonary disease and > 10 pack years smoking history

Tiotropium probably leads to lower patients with 1 or more exacerbations compared with long‐acting beta‐agonists (moderate certainty).

1 finding from 1 review