Cochrane · systematic review · CD006829
Combined corticosteroid and long‐acting beta₂‐agonist in one inhaler versus long‐acting beta₂‐agonists for chronic obstructive pulmonary disease
Nannini, LJ, Lasserson, TJ, Poole, P · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 20%Low 1 · 20%Moderate 3 · 60%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Combined inhalers compared to LABAs for COPD
Population: COPD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Annual Exacerbation Rates Combined inhalers vs LABAs | Rate ratio 0.76 [0.68, 0.84] | 9 studies · 99211 participants | Low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Number of people experiencing one or more exacerbations Combined inhalers vs LABAs | OR 0.83 [0.7, 0.98] | 6 studies · 3357 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Annual hospitalisation rates Combined inhalers vs LABAs | Rate ratio 0.79 [0.55, 1.13] | 3 studies · 48791 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Mortality Combined inhalers vs LABAs | OR 0.92 [0.76, 1.11] | 10 studies · 10681 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Pneumonia Combined inhalers vs LABAs | OR 1.55 [1.2, 2.01] | 12 studies · 11076 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, publication bias |