Cochrane · systematic review · CD009157
Tiotropium versus long‐acting beta‐agonists for stable chronic obstructive pulmonary disease
Chong, J, Karner, C, Poole, P · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 25%Very low 1 · 25%Low 1 · 25%Moderate 1 · 25%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Tiotropium versus long‐acting beta‐agonists for stable chronic obstructive pulmonary disease
Population: patients with stable chronic obstructive pulmonary disease and > 10 pack years smoking history
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Quality of life (SGRQ) Tiotropium vs long‐acting beta‐agonists | no estimate extracted | 4 studies · 4935 participants | Ungraded |
Patients with 1 or more exacerbations Tiotropium vs long‐acting beta‐agonists | OR 0.86 [0.79, 0.93] | 6 studies · 12123 participants | Moderate Downgraded: risk of bias |
Mortality (all‐cause) Tiotropium vs long‐acting beta‐agonists | OR 0.82 [0.6, 1.13] | 6 studies · 12123 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Cost‐effectiveness Tiotropium vs long‐acting beta‐agonists | no estimate extracted | 6 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |