Cochrane · systematic review · CD000525
Zuclopenthixol acetate for acute schizophrenia and similar serious mental illnesses
Jayakody, K, Gibson, RC, Kumar, A, et al. · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
11
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 3 · 27.3%Very low 0 · 0%Low 8 · 72.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
ZUCLOPENTHIXOL ACETATE versus STANDARD DRUG CARE for acute schizophrenia and similar serious mental illnesses
Population: patients with acute schizophrenia and similar serious mental illnesses
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Sedation/tranquillisation: Not sedated ‐ at four hours ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE | RR 0.74 [0.54, 1] | 1 study · 40 participants | Low Downgraded: risk of bias, imprecision |
Global state: 1. Requiring supplementary medication ‐ antipsychotics ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE | RR 1.49 [0.97, 2.3] | 3 studies · 134 participants | Low Downgraded: risk of bias, imprecision |
Global state: 2. Requiring 3 or more injections ‐ over 7 days ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE | RR 0.39 [0.18, 0.84] | 1 study · 70 participants | Low Downgraded: risk of bias, imprecision |
Mental state: 1. No important improvement ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE | RR 0.86 [0.39, 1.86] | 2 studies · 188 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects: Movement disorders ‐ dystonia (spasmodic postural disorder) ‐ by 24 hours ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE | RR 0.68 [0.34, 1.36] | 3 studies · 242 participants | Low Downgraded: risk of bias, imprecision |
ZUCLOPENTHIXOL ACETATE (HIGH DOSE) compared to ZUCLOPENTHIXOL ACETATE (LOW DOSE) for acute schizophrenia and similar serious mental illnesses
Population: patients with acute schizophrenia and similar serious mental illnesses
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Sedation/tranquillisation: Not sedated ‐ at two hours ZUCLOPENTHIXOL ACETATE (HIGH DOSE) vs ZUCLOPENTHIXOL ACETATE (LOW DOSE) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Global state: 1. Requiring supplementary medication ‐ antipsychotics ZUCLOPENTHIXOL ACETATE (HIGH DOSE) vs ZUCLOPENTHIXOL ACETATE (LOW DOSE) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Global state: 2. Requiring 3 or more injections ‐ over 7 days ZUCLOPENTHIXOL ACETATE (HIGH DOSE) vs ZUCLOPENTHIXOL ACETATE (LOW DOSE) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Mental state: 1. Not markedly improved (BPRS, < 60% decrease in BPRS score) ZUCLOPENTHIXOL ACETATE (HIGH DOSE) vs ZUCLOPENTHIXOL ACETATE (LOW DOSE) | RR 1 [0.51, 1.95] | 1 study · 30 participants | Low Downgraded: risk of bias, imprecision |
Mental state: 2. Not improved (BPRS, < 30% decrease in BPRS score) ZUCLOPENTHIXOL ACETATE (HIGH DOSE) vs ZUCLOPENTHIXOL ACETATE (LOW DOSE) | RR 0.6 [0.17, 2.07] | 1 study · 30 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects: 1. Extrapyramidal side effects (TESS) ZUCLOPENTHIXOL ACETATE (HIGH DOSE) vs ZUCLOPENTHIXOL ACETATE (LOW DOSE) | RR 2.33 [0.74, 7.35] | 1 study · 30 participants | Low Downgraded: risk of bias, imprecision |