Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

277 questions · 281 findings · 52 reviews · Developmental, Psychosocial and Learning Problems

No studies found 54 · 19.2%GRADE not reported 13 · 4.6%Very low 64 · 22.8%Low 71 · 25.3%Moderate 69 · 24.6%High 10 · 3.6%

Intermittent iron supplementation (alone or with any other micronutrients) vs no supplementation or placebo

Iron deficiency anaemia · adolescent and adult menstruating women

Intermittent iron supplementation (alone or with any other… showed no clear difference in iron deficiency anaemia (as defined by the presence of anaemia plus… compared with no supplementation or placebo (low certainty).

1 finding from 1 review

Methylphenidate vs placebo

Tic severity Measured by standardized rating scales: Yale Global Tic Severity Scale, Tourette Syndrome Severity Scale, Global Tic Rating Scale, Tic Symptom Self‐Report, Hopkins Motor/Vocal Scale · children with ADHD and comorbid tic disorders
1 finding from 1 review

Intervention not reported

Communication and language skills: expressive language Measured by: standardized measures of expressive language (higher scores indicate better expressive language skills) · patients with young children (less than six years old) with autism spectrum disorders (ASD)
1 finding from 1 review

Parent‐ and clinician‐mediated intervention vs clinician‐mediated intervention alone

Expressive language (number of words; standard scores; MLUw; NDW; IPSyn; frequency of unique targets; % target talk) · children with Down syndrome aged between birth and six years
1 finding from 1 review

Summary of findings: Picture Exchange Communication System (PECS) vs treatment

Spoken communication Measured by: frequency of speech, including non‐word vocalisations (expressed as rates per minute)a · minimally verbal children with autism spectrum disorder

It is very uncertain whether summary of findings: Picture Exchange Communication System (PECS) changes spoken communication Measured by: frequency of speech, including… compared with treatment (very low certainty).

1 finding from 1 review

Summary of findings: Picture Exchange Communication System (PECS) vs treatment

Non‐verbal communication/AAC Measured by: frequency of use of PECS symbols (expressed as rates per minute)a · minimally verbal children with autism spectrum disorder

It is very uncertain whether summary of findings: Picture Exchange Communication System (PECS) changes non‐verbal communication/AAC Measured by: frequency of use of PECS… compared with treatment (very low certainty).

1 finding from 1 review

Summary of findings: Picture Exchange Communication System (PECS) vs treatment

Combined spoken and non‐verbal communication/AAC · minimally verbal children with autism spectrum disorder

It is very uncertain whether summary of findings: Picture Exchange Communication System (PECS) changes combined spoken and non‐verbal communication/AAC Measured by: verbal… compared with treatment (very low certainty).

1 finding from 1 review

Intervention not reported

Proportion of responders (Clinical Global Impressions ‐ Improvement (CGI‐I) scale) · children or adolescents with ADHD

It is very uncertain whether the intervention changes proportion of responders (Clinical Global Impressions ‐ Improvement… (very low certainty).

1 finding from 1 review

Intensive advocacy interventions for women who experience intimate partner abuse vs (Optimised) usual care

Overall abuse One study used a composite of two scales (12 items. Scale from 0 to 36) Other study used Composite Abuse Scale (CAS)i (30 items presented in a 6‐point format requiring respondents to answer 'never', 'only once', 'several times', 'mon... · women with intimate partner abuse
1 finding from 1 review