Cochrane · systematic review · CD007990
Pharmacological treatment for attention deficit hyperactivity disorder (ADHD) in children with comorbid tic disorders
Osland, ST, Steeves, TDL, Pringsheim, T · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Developmental, Psychosocial and Learning ProblemsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 33.3%Low 4 · 66.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Methylphenidate compared with placebo for attention deficit hyperactivity disorder (ADHD) in children with comorbid tic disorders
Population: children with ADHD and comorbid tic disorders
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
ADHD symptom‐related behavior Measured by standardized rating scales: Conners' Abbreviated Teacher Rating Scale, Conners' Abbreviated Parent Rating Scale, IOWA Conners' Teacher Rating Scale, Mothers' Objective Method for Subgrouping, Continuous Pe... Methylphenidate vs placebo | no estimate extracted | 3 studies · 229 participants | Low Downgraded: risk of bias, imprecision |
Tic severity Measured by standardized rating scales: Yale Global Tic Severity Scale, Tourette Syndrome Severity Scale, Tourette Syndrome Clinical Global Impression Scale, Global Tic Rating Scale, 2‐Minute Tic and Habit Count, Tic Symptom Self‐Report Methylphenidate vs placebo | no estimate extracted | 3 studies · 229 participants | Low Downgraded: risk of bias, imprecision |
Clonidine compared with placebo for attention deficit hyperactivity disorder (ADHD) in children with comorbid tic disorders
Population: children with ADHD and comorbid tic disorders
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
ADHD symptom‐related behavior Measured by standardized rating scales: Conners' Abbreviated Teacher Rating Scale, Conners' Abbreviated Parent Rating Scale, IOWA Conners' Teacher Rating Scale, Conners' Continuous Performance Task, Child Behaviour Ch... Clonidine vs placebo | no estimate extracted | 2 studies · 170 participants | Low Downgraded: risk of bias, imprecision |
Tic severity Measured by standardized rating scales: Yale Global Tic Severity Scale, Tourette Syndrome Severity Scale, Global Tic Rating Scale, Tic Symptom Self‐Report, Hopkins Motor/Vocal Scale Clonidine vs placebo | no estimate extracted | 2 studies · 170 participants | Low Downgraded: risk of bias, imprecision |
Desipramine compared with placebo for attention deficit hyperactivity disorder (ADHD) in children with comorbid tic disorders
Population: children with ADHD and comorbid tic disorders
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
ADHD symptom‐related behavior Measured by standardized rating scales: Child Behaviour Checklist, Gordon Diagnostic System, Clinical Evaluation of Language Function, Matching Familial Figures Test, Porteus Maze Test, Restricted Academic Test, ADHD ... Desipramine vs placebo | no estimate extracted | 2 studies · 75 participants | Very low Downgraded: risk of bias, imprecision |
Tic severity Measured by standardized rating scales: Yale Global Tic Severity Scale, Tourette Syndrome Severity Scale, Hopkins Motor/Vocal Scale; ADHD Parent Linear Analogue Scale Desipramine vs placebo | no estimate extracted | 2 studies · 75 participants | Very low Downgraded: risk of bias, imprecision |