Cochrane · systematic review · CD009996
Amphetamines for attention deficit hyperactivity disorder (ADHD) in children and adolescents
Punja, S, Shamseer, L, Hartling, L, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Developmental, Psychosocial and Learning ProblemsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 57.1%Low 3 · 42.9%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: children or adolescents with ADHD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total ADHD symptom score ‐ parent ratings (ADHD Rating Scale, Fourth Version; Conners' Rating Scale; Conners' Global Index; Conners' Abbreviated Symptom Questionnaire) | no estimate extracted | 7 studies · 1247 participants | Very low Downgraded: risk of bias, inconsistency |
Total ADHD symptom score ‐ teacher ratings (ADHD Rating Scale, Fourth Version; Conners' Rating Scale; Conners' Global Index; Conners' Abbreviated Symptom Questionnaire) | no estimate extracted | 5 studies · 745 participants | Low Downgraded: risk of bias |
Total ADHD symptom score ‐ clinician ratings (ADHD Rating Scale, Fourth Version) | no estimate extracted | 3 studies · 813 participants | Very low Downgraded: risk of bias, inconsistency |
Proportion of responders (Clinical Global Impressions ‐ Improvement (CGI‐I) scale) | RR 3.36 [2.48, 4.55] | 9 studies · 2207 participants | Very low Downgraded: risk of bias, inconsistency |
Academic performance (Permanent Product Measure of Performance; Wechsler Intelligence Scale for Children ‐ Revised; Barnell Lot, Ltd Math Test; Wide Range Achievement Test) | SMD 0.56 [0.39, 0.73] | 8 studies · 826 participants | Low Downgraded: risk of bias |
Retention: proportion of participants who completed the trial | RR 1.03 [0.97, 1.1] | 11 studies · 2381 participants | Very low Downgraded: risk of bias, inconsistency |
Proportion of participants who experienced at least 1 adverse event | RR 1.3 [1.18, 1.44] | 6 studies · 1742 participants | Low Downgraded: risk of bias |