Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,315 questions · 23,557 findings · 2,311 reviews

No studies found 4,183 · 17.8%GRADE not reported 3,930 · 16.7%Very low 5,371 · 22.8%Low 5,787 · 24.6%Moderate 3,320 · 14.1%High 966 · 4.1%

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Lower blood pressure targets vs standard blood pressure targets

Cardiovascular mortality · cardiovascular disease with high blood pressure

Lower blood pressure targets showed no clear difference in cardiovascular mortality compared with standard blood pressure targets (moderate certainty).

1 finding from 1 review

Lower blood pressure targets vs standard blood pressure targets

Withdrawals due to adverse events · cardiovascular disease with high blood pressure

It is very uncertain whether lower blood pressure targets changes participant withdrawals due to adverse effects compared with standard blood pressure targets (very low certainty).

1 finding from 1 review

Maternal smoking during pregnancy vs No maternal smoking during pregnancy

Dental caries in children · Children of mothers assessed for smoking status during pregnancy (early childhood dental caries)

In the USA study, maternal smoking during pregnancy was associated with increased odds of childhood dental caries (OR 1.85, 95% CI 1.38 to 2.49).

15 findings from 1 review
Show 12 more findings

Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)

Proportion of ancient skulls with at least one non-carious cervical lesion (NCCL) · Ancient/prehistoric human skulls (excavated/archaeological skeletal remains)

About 1.4% of ancient skulls (pooled) had at least one NCCL; crude 17/805 (2.11%) across 6 studies (ungraded, substantial heterogeneity I2=69%).

1 finding from 1 review

Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)

Proportion of teeth with non-carious cervical lesions (NCCLs) in ancient skulls · Ancient/prehistoric human skulls (excavated/archaeological skeletal remains)

Non-carious cervical lesions affected a pooled proportion of about 0.4% of teeth in ancient skulls (4 studies; ungraded, very high heterogeneity I2=97.6%).

1 finding from 1 review

Reduction in previous year's academic score vs No reduction in academic score

Reduction in previous year's academic score · Primary school children in Ethiopia

Dental caries was associated with higher odds of a reduction in the previous year's academic score (OR 5.51, 95% CI 1.952-9.066; ungraded).

1 finding from 1 review

NIPPV vs NCPAP

Respiratory failure post extubation · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) probably leads to lower respiratory failure postextubation compared with nasal continuous positive airway pressure (NCPAP) (moderate certainty).

1 finding from 1 review

NIPPV vs NCPAP

Gastrointestinal perforation · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in gastrointestinal perforation compared with nasal continuous positive airway pressure (NCPAP) (low certainty).

1 finding from 1 review

NIPPV vs NCPAP

Necrotising enterocolitis · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in necrotising enterocolitis compared with nasal continuous positive airway pressure (NCPAP) (moderate certainty).

1 finding from 1 review

NIPPV vs NCPAP

Chronic lung disease · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in chronic lung disease (oxygen supplementation at 36 weeks) compared with nasal continuous positive airway pressure (NCPAP) (moderate certainty).

1 finding from 1 review

NIPPV vs NCPAP

Mortality before hospital discharge · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in mortality (defined as death before discharge) compared with nasal continuous positive airway pressure (NCPAP) (low certainty).

1 finding from 1 review

Summary of findings table ‐ Preoperative exercise training vs no exercise

Exercise capacity · people scheduled to undergo lung resection for non‐small cell lung cancer
2 findings from 1 review

Interventions for increasing immunosuppressant medication adherence vs usual care

Proportion of immunosuppressant trough concentration levels at target · solid organ transplant recipients

It is very uncertain whether interventions for increasing immunosuppressant medication adherence changes proportion of immunosuppressant trough concentration levels at target compared with standard care (very low certainty).

1 finding from 1 review

Prenatal vitamin D deficiency (low maternal 25(OH)D during pregnancy) vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D)

Dental caries in children · Infants and children (aged about 2 to 8 years) whose mothers' vitamin D status was assessed during pregnancy

For prenatal vitamin D measured across gestational weeks 6-38, the OR of dental caries was 1.32 (no CI reported); ungraded.

3 findings from 1 review