Cochrane · systematic review · CD012854
Interventions for increasing immunosuppressant medication adherence in solid organ transplant recipients
Mellon, L, Doyle, F, Hickey, A, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 42.9%Low 4 · 57.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Interventions for increasing immunosuppressant medication adherence versus standard care in solid organ transplant recipients
Population: solid organ transplant recipients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Taking adherence Interventions for increasing immunosuppressant medication adherence vs standard care | RR 1.09 [0.95, 1.27] | 4 studies · 445 participants | Low Downgraded: inconsistency |
Dosing adherence Interventions for increasing immunosuppressant medication adherence vs standard care | RR 1.14 [1.03, 1.26] | 8 studies · 713 participants | Low Downgraded: inconsistency |
Timing adherence Interventions for increasing immunosuppressant medication adherence vs standard care | RR 1.1 [0.98, 1.23] | 6 studies · 632 participants | Low Downgraded: inconsistency |
Drug holidays Interventions for increasing immunosuppressant medication adherence vs standard care | RR 1.12 [0.77, 1.62] | 4 studies · 445 participants | Low Downgraded: inconsistency |
Self‐reported adherence (proportion) Interventions for increasing immunosuppressant medication adherence vs standard care | RR 1.21 [0.99, 1.49] | 9 studies · 755 participants | Very low Downgraded: inconsistency |
Self‐reported adherence (mean) Interventions for increasing immunosuppressant medication adherence vs standard care | no estimate extracted | 5 studies · 471 participants | Very low Downgraded: inconsistency |
Proportion of immunosuppressant trough concentration levels at target Interventions for increasing immunosuppressant medication adherence vs standard care | RR 0.98 [0.68, 1.4] | 4 studies · 348 participants | Very low Downgraded: inconsistency |