Question · asked by 1 review

Lower blood pressure targets vs standard blood pressure targets: Withdrawals due to adverse events

Population
cardiovascular disease with high blood pressure
Intervention
Lower blood pressure targets
Comparison
standard blood pressure targets
Outcome
Withdrawals due to adverse events

It is very uncertain whether lower blood pressure targets changes participant withdrawals due to adverse effects compared with standard blood pressure targets (very low certainty).

What each review found

Include earlier review versions
FindingEffectStudiesGRADE certainty
Lower blood pressure targets vs standard blood pressure targets
Participant withdrawals due to adverse effects · cardiovascular disease with high blood pressure
It is very uncertain whether lower blood pressure targets changes participant withdrawals due to adverse effects compared with standard blood pressure targets (very low certainty).
Blood pressure targets for the treatment of people with hypertension and cardiovascular disease (2022) · Cochrane Headline outcomes only
RR 8.16 [2.06, 32.28]3 studies · 801 participantsVery low

Findings are shown side by side, never pooled across reviews.

The reviews

ReviewSearched up toIncluded studiesAMSTAR 2
Blood pressure targets for the treatment of people with hypertension and cardiovascular disease
2022 · Cochrane Headline outcomes only
Not reportedNot extractedNot assessed
How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.