Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

418 questions · 423 findings · 44 reviews · Eyes and Vision

No studies found 122 · 28.8%GRADE not reported 26 · 6.1%Very low 98 · 23.2%Low 120 · 28.4%Moderate 53 · 12.5%High 4 · 0.9%

Summary of findings 1: blue‐light filtering lenses vs non blue‐light filtering IOL

Proportion of participants with adverse events with a probable causal link with the study interventions at six months · adults

Summary of findings 1: blue‐light filtering lenses may leads to lower proportion of participants with adverse events with a probable… compared with non‐blue‐light filtering lenses (low certainty).

1 finding from 1 review

Phacoemulsification vs laser peripheral iridotomy

Proportion of participants requiring further IOP‐lowering interventions (additional surgery, medications, or both) (lower number of events is better) · Participants with acute primary angle closure after initial medical treatment to lower intraocular pressure

It is very uncertain whether phacoemulsification changes proportion of participants requiring further IOP‐lowering… compared with laser peripheral iridotomy (very low certainty).

1 finding from 1 review

Binocular iPad treatment vs occlusion therapy

Measurable change in stereopsis after 8 (± 2) weeks and 16 (± 2) weeks of intervention 'Real change' in stereopsis is defined as a change in stereoacuity of two or more octaves. · 5‐ to 8‐year‐old children with amblyopia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Further surgical or laser interventions · adults with PACS or PAC, and previous PI

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Further surgical or laser interventions · adults with PAC or PACG, and previous PI
1 finding from 1 review

Standard treatment plus systemic corticosteroids vs usual care

Surgical intervention · patients age 10 years and older with periorbital or orbital cellulitis

It is very uncertain whether standard treatment plus systemic corticosteroids changes need for surgical intervention compared with standard treatment alone (very low certainty).

1 finding from 1 review

Oral antibiotics vs placebo

Economic costs and benefits of different interventions · adult participants with chronic blepharitis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Pain control change from baseline 12 months postintervention · adults with refractory glaucoma

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Mean change in IOP measured in mmHg 12 months postintervention · adults with refractory glaucoma
1 finding from 1 review

Intervention not reported

Mean change in best‐corrected visual acuity measured by logMAR 12 months postintervention · adults with refractory glaucoma
1 finding from 1 review