evidence/gaps
Cochrane · systematic review · CD013697

Oral antibiotics for chronic blepharitis

Onghanseng, N, Ng, SM, Halim, MS, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library

Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
4
No studies
3
Included studies
NR
No studies 3 · 42.9%Ungraded 0 · 0%Very low 4 · 57.1%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Oral antibiotics compared with placebo for chronic blepharitis

Population: adult participants with chronic blepharitis
7 questions
OutcomeEffectEvidenceStatus / GRADE
Subjective improvement in symptoms at 1 month and 3 months
Oral antibiotics vs placebo
no estimate extracted1 study · 70 participantsVery low
Downgraded: risk of bias, imprecision, inconsistency
Measurements of eradication or decrease in numbers of colonies of positive cultures of bacteria
Oral antibiotics vs placebo
no estimate extractedNRNo studies
Clinical signs—Schirmer test scores at 1 month (mm/5 min)
Oral antibiotics vs placebo
no estimate extracted1 study · 93 participantsVery low
Downgraded: risk of bias, imprecision
Clinical signs—TBUT at 1 month (seconds)
Oral antibiotics vs placebo
no estimate extracted1 study · 93 participantsVery low
Downgraded: risk of bias, imprecision
Adverse events at 1 month
Oral antibiotics vs placebo
RR 6.13 [1.94, 19.41]1 study · 93 participantsVery low
Downgraded: risk of bias, imprecision
Quality of life measures
Oral antibiotics vs placebo
no estimate extractedNRNo studies
Economic costs and benefits of different interventions
Oral antibiotics vs placebo
no estimate extractedNRNo studies