Cochrane · systematic review · CD012131

Adjunctive steroid therapy versus antibiotics alone for acute endophthalmitis after intraocular procedure

Emami, S, Kitayama, K, Coleman, AL · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library

Eyes and Vision2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 3 · 37.5%Ungraded 0 · 0%Very low 1 · 12.5%Low 4 · 50%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

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Combined steroid and antibiotic therapy compared with antibiotics alone for acute endophthalmitis after intraocular procedure

Population: eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)

8 questions

Outcome	Effect	Evidence	Status / GRADE
Outcomes* Combined steroid and antibiotic therapy vs antibiotics alone	no estimate extracted	NR	No studies
Complete resolution of endophthalmitis at 3 months' Combined steroid and antibiotic therapy vs antibiotics alone	RR 1.08 [0.8, 1.45]	1 study · 32 participants	Very low Downgraded: risk of bias, imprecision, indirectness
Visual acuity 6/6 to 6/18 at 3 months' Combined steroid and antibiotic therapy vs antibiotics alone	RR 1.95 [1.05, 3.6]	2 studies · 60 participants	Low Downgraded: risk of bias, imprecision
Visual acuity 6/6 to 6/18, or LogMAR 0.3 or better at 12 months' Combined steroid and antibiotic therapy vs antibiotics alone	RR 1.12 [0.92, 1.37]	2 studies · 195 participants	Low Downgraded: risk of bias, imprecision
Improvement in visual acuity at 3 months' Combined steroid and antibiotic therapy vs antibiotics alone	no estimate extracted	NR	No studies
Intraocular pressure at 12 months' Combined steroid and antibiotic therapy vs antibiotics alone	no estimate extracted	1 study · 167 participants	Low Downgraded: imprecision
Adverse events at 3 to 12 months' Combined steroid and antibiotic therapy vs antibiotics alone	RR 1.41 [0.53, 3.74]	3 studies · 227 participants	Low Downgraded: risk of bias, imprecision
Costs associated with the interventions at 3 months' Combined steroid and antibiotic therapy vs antibiotics alone	no estimate extracted	NR	No studies