Cochrane · systematic review · CD012131
Adjunctive steroid therapy versus antibiotics alone for acute endophthalmitis after intraocular procedure
Emami, S, Kitayama, K, Coleman, AL · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
5
No studies
3
Included studies
NR
No studies 3 · 37.5%Ungraded 0 · 0%Very low 1 · 12.5%Low 4 · 50%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyCombined steroid and antibiotic therapy compared with antibiotics alone for acute endophthalmitis after intraocular procedure
Population: eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Outcomes* Combined steroid and antibiotic therapy vs antibiotics alone | no estimate extracted | NR | No studies |
Complete resolution of endophthalmitis at 3 months' Combined steroid and antibiotic therapy vs antibiotics alone | RR 1.08 [0.8, 1.45] | 1 study · 32 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Visual acuity 6/6 to 6/18 at 3 months' Combined steroid and antibiotic therapy vs antibiotics alone | RR 1.95 [1.05, 3.6] | 2 studies · 60 participants | Low Downgraded: risk of bias, imprecision |
Visual acuity 6/6 to 6/18, or LogMAR 0.3 or better at 12 months' Combined steroid and antibiotic therapy vs antibiotics alone | RR 1.12 [0.92, 1.37] | 2 studies · 195 participants | Low Downgraded: risk of bias, imprecision |
Improvement in visual acuity at 3 months' Combined steroid and antibiotic therapy vs antibiotics alone | no estimate extracted | NR | No studies |
Intraocular pressure at 12 months' Combined steroid and antibiotic therapy vs antibiotics alone | no estimate extracted | 1 study · 167 participants | Low Downgraded: imprecision |
Adverse events at 3 to 12 months' Combined steroid and antibiotic therapy vs antibiotics alone | RR 1.41 [0.53, 3.74] | 3 studies · 227 participants | Low Downgraded: risk of bias, imprecision |
Costs associated with the interventions at 3 months' Combined steroid and antibiotic therapy vs antibiotics alone | no estimate extracted | NR | No studies |
Combined steroid and antibiotic therapy compared with antibiotics alone for acute endophthalmitis after intraocular procedure
Population: eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Outcomes* Combined steroid and antibiotic therapy vs antibiotics alone | no estimate extracted | NR | No studies |
Complete resolution of endophthalmitis at 3 months' Combined steroid and antibiotic therapy vs antibiotics alone | RR 1.08 [0.8, 1.45] | 1 study · 32 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Visual acuity 6/6 to 6/18 at 3 months' Combined steroid and antibiotic therapy vs antibiotics alone | RR 1.95 [1.05, 3.6] | 2 studies · 60 participants | Low Downgraded: risk of bias, imprecision |
Improvement in visual acuity at 3 months' Combined steroid and antibiotic therapy vs antibiotics alone | no estimate extracted | NR | No studies |
Intraocular pressure at 3 months' Combined steroid and antibiotic therapy vs antibiotics alone | no estimate extracted | NR | No studies |
Adverse events at 3 months' Combined steroid and antibiotic therapy vs antibiotics alone | RR 1.57 [0.5, 4.9] | 2 studies · 60 participants | Very low Downgraded: risk of bias, imprecision |
Costs associated with the interventions at 3 months' Combined steroid and antibiotic therapy vs antibiotics alone | no estimate extracted | NR | No studies |