Caries arrestment at the individual (patient) level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
Pooling two trials, nano-silver fluoride achieved higher individual-level caries arrestment than SDF (OR 0.39 favoring the comparator; ungraded subgroup).
1 finding from 1 review
Intervention not reported
Serum vitamin D (25(OH)D): ECC vs caries-free
The intervention led to lower serum vitamin D (25(OH)D): ECC vs caries-free; GRADE not reported.
1 finding from 1 review
Dental caries · Children (<18 years) with vs without dental caries
FokI(rs2228570) dominant model: AA+AG vs GG was not significantly associated with dental caries (OR 1.07); ungraded.
1 finding from 1 review
Rotation of the mandibular second premolar · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
After mandibular first molar extraction, the second premolar was rotated in about 60% of cases (2 studies; very imprecise; not GRADE-rated).
1 finding from 1 review
Intervention not reported
Overall success (composite of clinical and radiographic success)
1 finding from 1 review
Dental caries in children · Children (approx. 4-18 years)
Pooling studies that used BMI as a continuous variable showed no significant association between per-unit BMI and childhood dental caries (OR 1.01, 95% CI 0.99 to 1.03; I2=3.5%); ungraded.
3 findings from 1 review
Enamel surface microhardness · Human tooth enamel specimens, sound/intact (in vitro)
In sound enamel, Er:YAG laser irradiation significantly increased surface microhardness after acid challenge versus untreated control (SMD 2.41, 95% CI 0.70 to 4.12; 3 in vitro studies; ungraded).
1 finding from 1 review
SMD 2.41 [0.70, 4.12]
3 studies
GRADE not reported
Dental caries · Children (<18 years) with vs without dental caries
ApaI(rs7975232) dominant model: CC+CA vs AA was not significantly associated with dental caries (OR 0.91); ungraded.
1 finding from 1 review
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the mandible, sex was not significantly associated with space closure (OR 1.38; not GRADE-rated).
1 finding from 1 review
Specificity · Children and adults with primary or permanent dentition undergoing dental caries assessment
Across 13 studies, the specificity of teledentistry caries diagnosis ranged from 83% to 100%; no pooled estimate and certainty not graded.
1 finding from 1 review
Dental caries · Children (<18 years) with vs without dental caries
Cdx-2(rs11568820) was reported by only one study and was not meta-analyzed; its association with caries risk is uncertain (ungraded).
1 finding from 1 review
Intervention not reported
Dental caries in children
The intervention led to higher dental caries in children; GRADE not reported.
1 finding from 1 review
OR 1.20 [1.04, 1.36]
4 studies
GRADE not reported
Caries experience (mean DMFT) · Brazilian children in primary dentition (BMI classified by CDC 2000 growth charts)
Overweight may make little or no difference to caries experience (dmft) in the primary dentition of Brazilian children (very low certainty).
1 finding from 1 review
Caries arrestment at the individual (patient) level · Children and adults without systemic diseases affecting dental health
SDF showed a higher caries-arrestment proportion at the individual level, but the reported difference was not statistically significant.
1 finding from 1 review
Dental caries · Children (<18 years) with vs without dental caries
TaqI/BglI(rs739837) dominant model: TT+TG vs GG was not significantly associated with dental caries (OR 1.09); ungraded.
1 finding from 1 review
Intervention not reported
Change in Lactobacillus spp. in dental plaque
1 finding from 1 review
High salivary P. gingivalis (over 10^4 CFU/ml) · adults
Periodontitis was associated with higher odds of detectable high-level salivary P. gingivalis (OR 3.38).
1 finding from 1 review
OR 3.38 [1.46, 7.83]
2 studies
GRADE not reported
Spontaneous space closure · Children and adolescents after extraction of a maxillary permanent first molar (before eruption of the second molar)
In the maxilla, extraction at Demirjian stage E (vs later F-H) increases odds of space closure (OR 4.78; low certainty).
1 finding from 1 review
Enamel resistance to demineralization (microhardness / lesion depth) · Human enamel adjacent to restorations or in pits and fissures (in situ / ex vivo)
Er:YAG laser showed a mixed and limited effect on enamel resistance to demineralization: feasible for controlling progression around restorations but not preventing caries formation, and ineffective in pits and fissures (ungraded, 2 ex-vivo studies, no pooled estimate).
1 finding from 1 review
Dental caries · Adults in case-control studies (oral cancer patients vs healthy controls)
The DMFT index was significantly higher in oral cancer patients than controls (SMD 0.65, 95% CI 0.12-1.18); ungraded.
1 finding from 1 review