Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,679 questions · 1,720 findings · 335 reviews · Headline outcomes only

No studies found 192 · 11.2%GRADE not reported 75 · 4.4%Very low 526 · 30.6%Low 504 · 29.3%Moderate 305 · 17.7%High 118 · 6.9%

Intervention not reported

Chlamydia prevalence (general population) Outcome was chlamydia test positivity after 3 yearly invitations in intervention clusters vs 1 invitation in control areas. Uptake was too low for chlamydia positivity to be considered an unbiased estimate... · healthy adults

The intervention showed no clear difference in chlamydia prevalence (general population) Outcome was chlamydia test… (low certainty).

1 finding from 1 review

Intervention not reported

Delayed open necrosectomy vs. early open necrosectomy · people with necrotising pancreatitis

It is very uncertain whether the intervention changes delayed open necrosectomy vs. early open necrosectomy (very low certainty).

1 finding from 1 review

Prophylactic oxytocin injection (delivered by community health officer) vs control (no injection)

Early infant death (0‐3 days) [ · pregnant women giving birth in non‐facility settings

Prophylactic oxytocin injection (delivered by community health… showed no clear difference in early infant death (0‐3 days) [ compared with control (no injection) (low certainty).

1 finding from 1 review

CHLORPROMAZINE vs RESERPINE

Leaving the study early ‐ due to adverse effects (short term) · patients with schizophrenia

CHLORPROMAZINE showed no clear difference in leaving the study early ‐ due to adverse effects (short term) compared with RESERPINE (moderate certainty).

1 finding from 1 review

Transmyocardial laser revascularization vs medical treatment

Early postoperative mortality Deaths in the 30 days after surgery · patients with refractory angina

Transmyocardial laser revascularization showed no clear difference in early postoperative mortality Deaths in the 30 days after surgery compared with medical treatment (high certainty).

1 finding from 1 review

Lithium as sole treatment vs placebo

Acceptability ‐ total dropouts · schizophrenia

Lithium as sole treatment showed no clear difference in acceptability of treatment leaving early due to any reason compared with placebo (low certainty).

1 finding from 1 review

Lithium vs antipsychotics

Acceptability ‐ total dropouts · schizophrenia

It is very uncertain whether lithium changes acceptability of treatment leaving early due to any reason compared with antipsychotics (very low certainty).

1 finding from 1 review

SUPPORTIVE THERAPY vs FAMILY THERAPY

Leaving the study early · patients with schizophrenia

It is very uncertain whether SUPPORTIVE THERAPY changes leaving the study early compared with FAMILY THERAPY (very low certainty).

1 finding from 1 review

SUPPORTIVE THERAPY vs PSYCHOEDUCATION

Leaving the study early · patients with schizophrenia

It is very uncertain whether SUPPORTIVE THERAPY changes leaving the study early compared with PSYCHOEDUCATION (very low certainty).

1 finding from 1 review