Cochrane · systematic review · CD012122
Chlorpromazine versus reserpine for schizophrenia
Nur, S, Adams, CE · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 14.3%Very low 1 · 14.3%Low 1 · 14.3%Moderate 4 · 57.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
CHLORPROMAZINE versus RESERPINE for schizophrenia
Population: patients with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Global state: Not improved (short term) CHLORPROMAZINE vs RESERPINE | RR 0.75 [0.62, 0.92] | 6 studies · 781 participants | Low Downgraded: risk of bias |
Mental state: Not improved (paranoid distortion) Multidimentional Scale for Rating Psychiatric Patients (short term) CHLORPROMAZINE vs RESERPINE | RR 1.33 [0.62, 2.89] | 1 study · 19 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Functioning: not improved occupational adjustment (short term) CHLORPROMAZINE vs RESERPINE | RR 0.83 [0.47, 1.47] | 1 study · 40 participants | Moderate Downgraded: indirectness |
Adverse events ‐ toxic reaction (short term) CHLORPROMAZINE vs RESERPINE | RR 1.68 [0.43, 6.54] | 3 studies · 210 participants | Moderate Downgraded: risk of bias |
Leaving the study early ‐ due to adverse effects (short term) CHLORPROMAZINE vs RESERPINE | RR 1.16 [0.94, 1.42] | 4 studies · 229 participants | Moderate Downgraded: risk of bias |
Behaviour: Not improved ‐ general (medium term) CHLORPROMAZINE vs RESERPINE | RR 0.79 [0.41, 1.53] | 1 study · 98 participants | Moderate Downgraded: risk of bias |
Quality of life: Not improved to an important extent CHLORPROMAZINE vs RESERPINE | no estimate extracted | 0 studies · 0 participants | Ungraded |