Cochrane · systematic review · CD000307
Fluphenazine decanoate (depot) and enanthate for schizophrenia
Maayan, N, Quraishi, SN, David, A, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
14
No studies
7
Included studies
NR
No studies 7 · 33.3%Ungraded 0 · 0%Very low 13 · 61.9%Low 1 · 4.8%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
FLUPHENAZINE DECANOATE compared with PLACEBO for schizophrenia
Population: patients with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death FLUPHENAZINE DECANOATE vs PLACEBO | RR 5 [0.25, 99.51] | 1 study · 54 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Relapse FLUPHENAZINE DECANOATE vs PLACEBO | RR 0.62 [0.24, 1.6] | 3 studies · 196 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Clinically significant change in global state ‐ not reported FLUPHENAZINE DECANOATE vs PLACEBO | no estimate extracted | NR | No studies |
Hospital admission ‐ not reported FLUPHENAZINE DECANOATE vs PLACEBO | no estimate extracted | NR | No studies |
Leaving the study early FLUPHENAZINE DECANOATE vs PLACEBO | RR 1.3 [0.77, 2.19] | 4 studies · 216 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Mental state BPRS FLUPHENAZINE DECANOATE vs PLACEBO | no estimate extracted | 1 study · 16 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Extrapyramidal adverse effects ‐ tardive dyskinesia FLUPHENAZINE DECANOATE vs PLACEBO | RR 0.83 [0.62, 1.11] | 1 study · 54 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
FLUPHENAZINE DECANOATE compared with ORAL NEUROLEPTICS for schizophrenia
Population: patients with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death ‐ not reported FLUPHENAZINE DECANOATE vs ORAL NEUROLEPTICS | no estimate extracted | NR | No studies |
Relapse FLUPHENAZINE DECANOATE vs ORAL NEUROLEPTICS | RR 1.46 [0.75, 2.83] | 6 studies · 419 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
No clinically important global change FLUPHENAZINE DECANOATE vs ORAL NEUROLEPTICS | RR 0.85 [0.56, 1.27] | 1 study · 102 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Hospital admission ‐ not reported FLUPHENAZINE DECANOATE vs ORAL NEUROLEPTICS | no estimate extracted | NR | No studies |
Leaving the study early FLUPHENAZINE DECANOATE vs ORAL NEUROLEPTICS | RR 0.96 [0.73, 1.25] | 10 studies · 937 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Mental state BPRS endpoint score FLUPHENAZINE DECANOATE vs ORAL NEUROLEPTICS | no estimate extracted | 1 study · 120 participants | Very low Downgraded: imprecision, publication bias |
Extrapyramidal adverse effects ‐ general FLUPHENAZINE DECANOATE vs ORAL NEUROLEPTICS | RR 0.47 [0.24, 0.91] | 3 studies · 259 participants | Very low Downgraded: imprecision, publication bias |
FLUPHENAZINE DECANAOTE compared to FLUPHENAZINE ENANTHATE for schizophrenia
Population: patients with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death ‐ not reported FLUPHENAZINE DECANAOTE vs FLUPHENAZINE ENANTHATE | no estimate extracted | NR | No studies |
Relapse FLUPHENAZINE DECANAOTE vs FLUPHENAZINE ENANTHATE | RR 2.43 [0.71, 8.32] | 1 study · 49 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Clinically significant change in global state ‐ not reported FLUPHENAZINE DECANAOTE vs FLUPHENAZINE ENANTHATE | no estimate extracted | NR | No studies |
Hospital admission ‐ not reported FLUPHENAZINE DECANAOTE vs FLUPHENAZINE ENANTHATE | no estimate extracted | NR | No studies |
Leaving the study early FLUPHENAZINE DECANAOTE vs FLUPHENAZINE ENANTHATE | RR 2.43 [0.71, 8.32] | 1 study · 49 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Mental State BPRS FLUPHENAZINE DECANAOTE vs FLUPHENAZINE ENANTHATE | no estimate extracted | 1 study · 39 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Extrapyramidal adverse effects ‐ general FLUPHENAZINE DECANAOTE vs FLUPHENAZINE ENANTHATE | RR 1.14 [0.79, 1.64] | 2 studies · 49 participants | Very low Downgraded: risk of bias, imprecision, publication bias |