Search review questions

Growth stunting / low linear growth (height-for-age z-score) · Children in early childhood (0-6 years) · Khanh et al. 2015 (Vietnam; pulp-involved caries)

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Gao,2013 [29]; model performance 5

Oral health-related quality of life (continuous), measured by OIDP / CPQ11-14 · Indian children and young adults

Secondary caries (occurrence) · Patients requiring dental restoration; deciduous (primary) teeth · 2 or more years of follow-up

Total mortality · Adults with oral cavity or oropharyngeal cancer · oral cavity

Root caries increment · Individuals of all ages · Follow-up ≥1 year, Hayes,2017 [33]; model performance 3

Shear bond strength (SBS) of metallic orthodontic brackets · Demineralized enamel of extracted permanent human teeth · Before bonding, Remineralization of WSLs (demineralized enamel)

Oral health-related quality of life · Adolescents aged 10-19 years

Early childhood caries (def-t/dmft caries experience) · Children in early childhood (0-6 years) · 2-year follow-up, Sokal-Gutierrez et al. 2016 (Ecuador; pre vs post intervention)

Secondary caries (occurrence) · Patients requiring dental restoration; deciduous (primary) teeth · 1 year of follow-up, Compomer

Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic…

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Birpou,2019 [25]; model performance 15

Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline) · 6 months to 3.5 years, Microbiological assessment: quantitative (culture/CFU counting)

Gingival Index (GI, Loe & Silness 1963) · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances) · <=3 months (short-term)

Pulp necrosis incidence · Vital teeth · > 5–10 years, > 5–10 years

Disease-free survival (new disease, progression, and mortality) · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes · 36 months

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Birpou,2019 [25]; model performance 8

Clinical and radiographic success (composite) · Patients with carious pulp exposure in permanent teeth undergoing pulpotomy (partial or full) · ≥6 months; follow-up range 1-2 years, Treatment performed: pulpotomy (FP/PP)

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Disney,1992 [15]; model performance 1

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Disney,1992 [15]; model performance 2

Clinical and radiographic success (composite) · Patients with carious pulp exposure in permanent teeth undergoing DPC or pulpotomy · ≥6 months follow-up

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Birpou,2019 [25]; model performance 1

Root caries increment · Individuals of all ages · Follow-up ≥1 year, Hayes,2017 [33]; model performance 2

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Hänsel Petersson,2010 [31]; model performance 5

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Gao.2010 [17]; model performance 2

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Birpou,2019 [25]; model performance 12

Remineralization/arrest of early enamel carious lesions · Patients with early enamel carious lesions on permanent molars · 24 months, Hamdi 2022

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Sánchez-Pérez,2009 [20]; model performance 1

Oral health-related quality of life (impact) · Untreated fractured tooth vs no trauma

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Hänsel Petersson,2010 [31]; model performance 1

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Hänsel Petersson,2015 [30]; model performance 2

MMP-2 activity/expression · Human carious dentin from irradiated and non-irradiated subjects

Bacterial collagenolytic enzymatic activity · Human ex vivo carious lesions / caries-associated biofilm

Pulp necrosis incidence · Vital teeth · Polyether

new root-surface carious lesions or restorations · older adults with root caries · 36 months

Adverse events associated with treatment · Adults with oral cavity or oropharyngeal cancer

Total mortality · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3) · 3 years

Clinical and radiographic success · Patients with carious pulp exposure in permanent teeth · 1 to 3 years, Unadjusted; all treatment modalities and root maturities

Gingival inflammation-related index · Orthodontic patients · ≤ 3 months

Adverse events associated with treatment · Adults with oral cavity cancer

Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years)

MMP-8 expression/activity · Human ex vivo carious dentin under sealed cavities · Before vs after sealing (Kuhn 2016: 60 days follow-up)

Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years)

Drooling Severity and Frequency Scale (DSFS) score · Adults with Parkinson's disease and sialorrhea (drooling) · Approximately 1 month post-injection (one study ~1 week)

Clinical and radiographic success (composite) · Patients with carious pulp exposure in mature permanent teeth · ≥6 months; follow-up range 1-3 years, Root maturation: mature

Periapical pathosis · Vital teeth restored with indirect restorations · >10 years, Follow-up >10 years

Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic…

Clinical and radiographic success · Patients with carious pulp exposure in permanent teeth undergoing direct pulp capping · 1 to 3 years, Direct pulp capping

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Beck,1992 [24]; model performance 6

Coronal caries increment · Individuals of all ages · Follow-up ≥1 year, Fontana,2011 [16]; model performance 9