Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

929 questions · 946 findings · 295 reviews · Headline outcomes only

No studies found 150 · 15.9%GRADE not reported 47 · 5%Very low 312 · 33%Low 262 · 27.7%Moderate 138 · 14.6%High 37 · 3.9%

Maintenance LTRA vs placebo

Number of participants experiencing one or more episode requiring treatment with oral steroids · episodic viral wheeze in children

Maintenance LTRA showed no clear difference in number of participants experiencing one or more episode requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Maintenance LTRA vs placebo

Number of participants experiencing one or more episodes requiring ED visit · episodic viral wheeze in children

Maintenance LTRA showed no clear difference in number of participants experiencing one or more episodes requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Maintenance LTRA vs placebo

Number of participants experiencing one or more episodes requiring hospital admission · episodic viral wheeze in children

Maintenance LTRA showed no clear difference in number of participants experiencing one or more episodes requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Intermittent LTRA vs placebo

Number of participants experiencing one or more episode requiring treatment with oral steroids · episodic viral wheeze in children

Intermittent LTRA showed no clear difference in number of participants experiencing one or more episode requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Intermittent LTRA vs placebo

Number of participants experiencing one or more episodes requiring ED visit · episodic viral wheeze in children

Intermittent LTRA showed no clear difference in number of participants experiencing one or more episodes requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Intermittent LTRA vs placebo

Number of participants experiencing one or more episodes requiring hospital admission · episodic viral wheeze in children

Intermittent LTRA showed no clear difference in number of participants experiencing one or more episodes requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Combined surgery vs phacoemulsification alone

Proportion using one or more medications at one year after surgery Number of participants · patients with eyes with cataract and glaucoma

Combined surgery may leads to lower proportion using one or more medications at one year after surgery… compared with phacoemulsification alone (low certainty).

1 finding from 1 review

Planned early birth vs expectant management

Major neonatal morbidity · pregnant women with a term suspected compromised baby

Planned early delivery showed no clear difference in major neonatal morbidity one or more of the following: hypoxic… compared with expectant management (low certainty).

1 finding from 1 review

Planned early birth vs expectant management

Significant maternal morbidity one or more of the following: significant postpartum haemorrhage requiring blood transfusion; maternal admission to intensive care unit; uterine rupture; hysterectomy · pregnant women with a term suspected compromised baby

Planned early delivery showed no clear difference in significant maternal morbidity one or more of the following:… compared with expectant management (low certainty).

1 finding from 1 review

Repetitive transcranial magnetic stimulation (rTMS) vs rTMS plus Tricyclic Anti‐depressant

Depression rating scale score · Post‐TBI Depression

It is very uncertain whether repetitive transcranial magnetic stimulation (rTMS) changes hamilton Rating Scale for Depression (HAM‐D); higher score means… compared with rTMS plus Tricyclic Anti‐depressant (very low certainty).

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Maternal anaemia at term (Hb less than 110 g/L at 37 weeks' gestation or more) (ALL) · Women receiving supplements in pregnancy

It is very uncertain whether any intermittent iron regimen (with or without other vitamins and… changes maternal anaemia at term (Hb less than 110 g/L at 37 weeks'… compared with daily regimen (with same vitamins and minerals)‐maternal outcomes (very low certainty).

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Maternal iron‐deficiency anaemia at term (Hb less than 110 g/L and at least 1 additional laboratory indicators at 37 weeks' gestation or more) · Women receiving supplements in pregnancy

It is very uncertain whether any intermittent iron regimen (with or without other vitamins and… changes maternal iron‐deficiency anaemia at term (Hb less than 110 g/L and… compared with daily regimen (with same vitamins and minerals)‐maternal outcomes (very low certainty).

1 finding from 1 review