Cochrane · systematic review · CD006259

Mitomycin C versus 5‐Fluorouracil for wound healing in glaucoma surgery

Cabourne, E, Clarke, JCK, Schlottmann, PG, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 1 · 14.3%Ungraded 0 · 0%Very low 0 · 0%Low 6 · 85.7%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

MMC compared to 5‐FU for wound healing in glaucoma surgery

Population: wound healing in glaucoma surgery

7 questions

Outcome	Effect	Evidence	Status / GRADE
Failure of functioning trabeculectomy at 1 year MMC vs 5‐FU	RR 0.65 [0.19, 2.2]	11 studies · 634 participants	Low Downgraded: risk of bias, imprecision
Intraocular pressure at 1 year MMC vs 5‐FU	no estimate extracted	7 studies · 386 participants	Low Downgraded: risk of bias, imprecision
Loss of 2 or more lines of Snellen visual acuity at 1 year MMC vs 5‐FU	RR 2 [0.53, 7.59]	5 studies · 328 participants	Low Downgraded: risk of bias, imprecision, inconsistency
Postoperative complications: late hypotony MMC vs 5‐FU	RR 1.37 [0.41, 4.63]	4 studies · 211 participants	Low Downgraded: risk of bias, imprecision, inconsistency
Postoperative complications: choroidal detachment MMC vs 5‐FU	RR 0.86 [0.45, 1.63]	8 studies · 494 participants	Low Downgraded: risk of bias, imprecision
Postoperative complications: endophthalmitis MMC vs 5‐FU	RR 3.89 [0.44, 34.57]	4 studies · 315 participants	Low Downgraded: risk of bias, imprecision
Quality of life at 1 year MMC vs 5‐FU	no estimate extracted	NR	No studies