Tiotropium vs ipratropium: Exacerbations
Tiotropium leads to lower patients with one or more exacerbations compared with ipratropium (high certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Tiotropium vs ipratropium Patients with one or more exacerbations · chronic obstructive pulmonary disease (COPD). Participants in included studies had an average baseline FEV1 of around… Tiotropium leads to lower patients with one or more exacerbations compared with ipratropium (high certainty). Tiotropium versus ipratropium bromide for chronic obstructive pulmonary disease (2015) · Cochrane Headline outcomes only | OR 0.71 [0.52, 0.95] | 2 studies · 1073 participants | High |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Tiotropium versus ipratropium bromide for chronic obstructive pulmonary disease 2015 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.