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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

10,375 questions in 429 reviews · Oral Health

current versions
No studies 1,344 · 13%Ungraded 6,832 · 65.9%Very low 1,228 · 11.8%Low 613 · 5.9%Moderate 290 · 2.8%High 68 · 0.7%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)
Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years) · Overall (all regions)
A systematic review and meta-analysis on early-childhood-caries global data. (2024)
MEAN 3.68 [2.99, 4.37]60 studiesUngraded
Postoperative systemic antibiotics (phenoxymethylpenicillin/penicillin VK, 7-day course), partial or total chemo-mechanical debridement and analgesics vs Matched placebo, partial or total chemo-mechanical debridement and analgesics
Pain at 7 days · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or… · 7 days
Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults (2024) · Cochrane
MD -0.05 [-0.41, 0.30]1 study · 41 participantsVery low
CC+AA (homozygous) genotypes vs CA (heterozygous) genotype
Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (CC+AA vs CA)
Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024)
OR 0.91 [0.73, 1.14]3 studies · 1327 participantsUngraded
Mineral trioxide aggregate (MTA) vs TotalFill BC
Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months
Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis… (2024)
OR 1.44 [0.65, 3.19]2 studies · 248 participantsUngraded
Facemask vs Untreated control (no treatment)
ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment (9 to 15 months)
Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children (2024) · Cochrane
MD 3.60 [2.68, 4.52]5 studies · 197 participantsUngraded
Children with severe early childhood caries (S-ECC) vs Caries-free children
Serum 25-hydroxyvitamin D level · Preschool children ≤6 years, North America · North America
The Association Between Vitamin D and Early Childhood Caries: A Systematic Review and Meta-Analysis. (2024)
MD -13.28 [-17.70, -8.87]NRUngraded
Facemask vs Untreated control (no treatment)
Adverse effects (temporomandibular joint signs and symptoms) · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment / follow-up
Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children (2024) · Cochrane
Mandall 2010: no statistical analysis of TMJ signs/symptoms due to low prevalence; at 6-year follow-up reported no adverse effects from facemask.1 study · 69 participantsUngraded
Abdominal dermal fat graft vs Nasolabial flap
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · Less than 3 months
Interventions for managing oral submucous fibrosis (2024) · Cochrane
MD -3.60 [-5.17, -2.03]1 study · 30 participantsVery low
Intralesional dexamethasone injections vs Placebo injections
Adverse effects · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Interventions for managing oral submucous fibrosis (2024) · Cochrane
Adverse effects (any): no adverse effects reported; 25 (1); no GRADE rating.1 study · 25 participantsUngraded
Extraction at patient age 8-10 years vs Extraction at patient age >10 years
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible
Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024)
OR 3.32 [1.73, 6.36]3 studies · 109 participantsLow
Occlusal splint vs Pharmacological therapy
Joint pain at rest · People with temporomandibular disorders (TMD) · Short term, Osteoarthritis / mixed TMD
Occlusal interventions for managing temporomandibular disorders (2024) · Cochrane
RR 1.87 [0.57, 6.07]1 study · 29 participantsVery low
Slum setting vs Non-slum urban setting
Oral disease prevalence · Adult residents of slum and non-slum urban settings in LMICs
Systematic review of oral health in slums and non-slum urban settings of Low and Middle-Income Countries… (2024)
no estimate extracted18 studiesUngraded
Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment
Quality of life · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Interventions for managing oral submucous fibrosis (2024) · Cochrane
The trials did not measure quality of life.0 studiesNo studies
Cranberry extract or cranberry flavonoid fractions vs No extract or vehicle control; other antimicrobial agents
Bacterial growth inhibition · Streptococcus mutans cultures and biofilms
Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus… (2024)
no estimate extracted7 studiesUngraded
Higher waist circumference vs Lower waist circumference
Dental caries in children · Children (approx. 4-18 years)
Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… (2024)
OR 1.08 [0.90, 1.30]2 studiesUngraded
Presence of oral Candida albicans vs Absence of oral Candida albicans
Early childhood caries (ECC) · Children aged ≤6 years (early childhood) · Exposure and outcome assessed concurrently (observational); children aged ≤6 years, Time period: 2018 and later
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A… (2024)
OR 4.17 [2.62, 6.64]12 studiesUngraded
GG genotype vs GA+AA genotypes
Dental caries · Children (<18 years) with vs without dental caries · Recessive model (GG vs GA+AA)
Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024)
OR 0.58 [0.26, 1.30]4 studies · 1741 participantsUngraded
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after subgingival instrumentation (SI) vs Subgingival instrumentation (SI) alone (hand or power-driven, or both), or SI plus placebo/sham aPDT
Quality of life · Adults (> 18 years) with recurrent periodontitis, receiving supportive (maintenance) periodontal care
Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri‐implant diseases (2024) · Cochrane
No studies reported data for this outcome.NRNo studies
Superelastic NiTi arch wire vs Multistrand stainless steel arch wire
Pain day 1 · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch) · 7 to 14 days
Initial arch wires used in orthodontic treatment with fixed appliances (2024) · Cochrane
MD 2.68 [-1.38, 6.75]2 studies · 127 participantsLow
Adhesive precoated (APC) flash-free brackets (minimal excess adhesive) vs Conventional brackets (conventional adhesive-coated / ceramic brackets)
Enamel demineralization / white spot lesions (DIAGNOdent, QLF) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35) · 1 to 6 months (to debonding)
Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed… (2024)
Two studies (Tan 2020 split-mouth, n=30; Yetkiner 2019 RCT, n=50): no statistically significant difference in demineralization between flash-free and conventional/APC brackets (Tan p>0.05; Yetkiner delta-F not…2 studies · 80 participantsUngraded
Silver diamine fluoride (SDF) plus fluoride varnish vs Sealants plus fluoride varnish (with or without restorations)
Dental pain or sensitivity · Children and adults (with or without carious lesions)
Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane
No studies reported data for this outcome in this comparison0 studiesNo studies
Occlusal splint vs No treatment or placebo (non-occlusal or transparent-foil placebo splint)
Recurrence rate · People with temporomandibular disorders (TMD)
Occlusal interventions for managing temporomandibular disorders (2024) · Cochrane
Listed in Summary of findings 1 as 'Not reported'; this outcome was not reported by any included study for this comparison. Recurrence rate was not reported in any included study across the whole review.0 studiesNo studies
Silver diamine fluoride (SDF; 38% in most trials, 30% in three) vs Other methods (pooled: ART/glass ionomer cement, nano-silver fluoride, sodium fluoride varnish, placebo)
Adverse effects (tooth staining; soft-tissue and systemic events) · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition) · up to 30 months
The role of silver diamine fluoride as dental caries preventive and arresting agent: a systematic review and… (2024)
Black staining of arrested lesions reported in most studies; 4 studies reported mild transient events (gingival blenching/pain; diarrhea/stomachache; burning, bad taste, pain, mouth injury, dissatisfaction with…NRUngraded
TT+CC (homozygous) genotypes vs TC (heterozygous) genotype
Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC), PCR-RFLP genotyping
Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024)
OR 1.15 [0.83, 1.60]NRUngraded
TT genotype vs TC+CC genotypes
Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TC+CC), Caucasian ethnicity
Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024)
OR 1.05 [0.56, 1.98]NRUngraded
Single preoperative dose of systemic antibiotics (clindamycin 600 mg), total chemo-mechanical debridement and root filling vs Matched placebo, total chemo-mechanical debridement and root filling
Swelling at 72 hours · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement) · 72 hours
Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults (2024) · Cochrane
No data available for this outcome.0 studiesNo studies
Teledentistry (index test): dental caries diagnosis from photographs taken with DSLR or smartphone cameras; store-and-forward vs Visual/clinical dental examination (reference standard)
Negative predictive value · Children and adults with primary or permanent dentition undergoing dental caries assessment · Cross-sectional diagnostic accuracy (index test vs reference standard, in-vivo), Overall (studies reporting NPV; narrative synthesis)
Teledentistry accuracy for caries diagnosis: a systematic review of in-vivo studies using extra-oral… (2024)
Negative predictive value reported in 10 of 19 studies; per-study values ranged from about 31% to 99.5% (Table 2). No pooled estimate.10 studiesUngraded
Intervention NR
Decayed surfaces (DS) · Periodontal disease severity (CDC-AAP); single study (Robert 2019); adjusted
Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024)
OR 1.18 [1.05, 1.32]1 studyUngraded
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after subgingival instrumentation (SI) vs Subgingival instrumentation (SI) alone (hand or power-driven, or both), or SI plus placebo/sham aPDT
Change in probing pocket depth (PPD) · Adults (> 18 years) with recurrent periodontitis, receiving supportive (maintenance) periodontal care · 3 months (change from baseline)
Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri‐implant diseases (2024) · Cochrane
MD 0.44 [-0.20, 1.08]6 studies · 244 participantsUngraded
Postoperative systemic antibiotics (phenoxymethylpenicillin/penicillin VK, 7-day course), partial or total chemo-mechanical debridement and analgesics vs Matched placebo, partial or total chemo-mechanical debridement and analgesics
Percussion pain at 48 hours · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or… · 48 hours
Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults (2024) · Cochrane
MD 0.09 [-0.44, 0.62]1 study · 41 participantsUngraded
Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)
Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years) · GNI $20000-$39999
A systematic review and meta-analysis on early-childhood-caries global data. (2024)
MEAN 1.13 [0.72, 1.55]9 studiesUngraded
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after subgingival instrumentation (SI) vs Subgingival instrumentation (SI) alone (hand or power-driven, or both), or SI plus placebo/sham aPDT
Change in gingival recession (REC) · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment · 6 months (change from baseline)
Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri‐implant diseases (2024) · Cochrane
MD 0.00 [-0.16, 0.16]4 studies · 95 participantsVery low
Facemask after Alt-RAMEC vs Facemask started simultaneously with Alt-RAMEC
Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment
Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children (2024) · Cochrane
MD 0.22 [-0.68, 1.12]1 study · 30 participantsUngraded
Silver diamine fluoride (SDF) vs Fluoride varnish
Adverse effects · Children and adults (with or without carious lesions) · 24 hours to 30 months, Children
Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults (2024) · Cochrane
In 1 study, black or brown staining on treated lesions was more common after SDF (OR 3.19, 95% CI 1.95 to 5.23), with no other adverse effects. 1 study reported complaints of a transient bitter taste with SDF use (with…3 studies · 980 participantsVery low
Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)
Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · GNI $10000-$19999
A systematic review and meta-analysis on early-childhood-caries global data. (2024)
Prevalence 55 [42, 68]9 studiesUngraded
Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)
Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · Gini index: low inequality
A systematic review and meta-analysis on early-childhood-caries global data. (2024)
Prevalence 39NRUngraded
Orthodontic removable traction appliance (ORTA) vs Untreated control (no treatment)
ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment
Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children (2024) · Cochrane
MD 3.81 [3.24, 4.38]1 study · 40 participantsUngraded
Occlusal splint vs Behavioural therapy (counselling, CBT, relaxation, self-care management)
Severity of joint noise · People with temporomandibular disorders (TMD)
Occlusal interventions for managing temporomandibular disorders (2024) · Cochrane
Listed in Summary of findings 4 as 'Not reported'; this outcome was not reported by any included study for this comparison.0 studiesNo studies
Obesity vs Normal weight (eutrophic)
Untreated dental caries (d component), continuous · Brazilian children/adolescents (BMI classified by WHO 2007 Z-score)
Overweight/obesity and dental caries in Brazilian children and adolescents: a systematic review and… (2024)
MD 0.28 [-0.03, 0.59]2 studies · 456 participantsLow
Serum 25(OH)D < 50 nmol/l vs Serum 25(OH)D 50–75 nmol/l
Early childhood caries (ECC) · Preschool children ≤6 years
The Association Between Vitamin D and Early Childhood Caries: A Systematic Review and Meta-Analysis. (2024)
OR 1.47 [1.30, 1.66]6 studies · 5265 participantsUngraded
Pulpotomy (full or partial) vs None (single-arm success proportion)
Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months
Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis… (2024)
Proportion 0.867 [0.820, 0.907]25 studies · 2012 participantsVery low
Slum / urban-disadvantaged setting vs Non-slum urban / general-urban / national population
Self-perceived (self-rated) oral health status · Adult residents of slums and non-slum urban settings of LMICs · Cross-sectional, By age, sex, socioeconomic class, employment
Systematic review of oral health in slums and non-slum urban settings of Low and Middle-Income Countries… (2024)
Six studies (incl. 1 qualitative) reported perception; most participants rated their oral health as satisfactory/good (e.g., Olutola 76% good; Olusile 21% very good + 37% good; Osuh higher in slum than non-slum),…6 studiesUngraded
Highest BMI category (overweight/obese) vs Lowest BMI category (normal weight/underweight)
Dental caries / early childhood caries (ECC) · Children (approx. 4-18 years) · Study design: cohort
Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… (2024)
OR 1.27 [1.07, 1.56]3 studiesUngraded
Overweight vs Normal weight (eutrophic)
Untreated dental caries (d component), continuous · Brazilian children/adolescents (BMI classified by WHO 2007 Z-score)
Overweight/obesity and dental caries in Brazilian children and adolescents: a systematic review and… (2024)
MD 0.03 [-0.24, 0.30]2 studies · 515 participantsLow
Superelastic NiTi arch wire vs Conventional (stabilised) NiTi arch wire
Alignment rate · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch) · 5 to 10 weeks
Initial arch wires used in orthodontic treatment with fixed appliances (2024) · Cochrane
Conventional NiTi vs superelastic NiTi (O'Brien 1990; Ong 2011); not pooled due to clinical heterogeneity; little or no difference in alignment rate2 studies · 124 participantsLow
Advice about a healthy diet (including breastfeeding promotion and sugar avoidance) and feeding practices (e.g. relating to bottle-feeding and sleep) for infants and young children vs Standard care
Child oral health behaviours · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,…
Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane
Two trials (Feldens 2007; Watt 2009) reported infant/child oral health behaviours; not suitable for meta-analysis. Both observed some evidence of benefit favouring the intervention.2 studiesUngraded
Facemask with rapid maxillary expansion (RME) vs Mini maxillary protractor
ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment
Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children (2024) · Cochrane
MD -0.75 [-1.49, -0.01]1 study · 32 participantsUngraded
Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)
Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · Life expectancy: highest (>80 years)
A systematic review and meta-analysis on early-childhood-caries global data. (2024)
Prevalence 28NRUngraded
Advice about a healthy diet (including breastfeeding promotion and sugar avoidance) and feeding practices (e.g. relating to bottle-feeding and sleep) for infants and young children vs Standard care
Adverse events for mother or child · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,…
Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane
One trial only (Feldens 2007) provided information on adverse events and reported no events.1 studyUngraded
Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)
Muscle pain at rest · People with temporomandibular disorders (TMD) · Short term (mean 4.4 weeks), Myofascial pain TMD
Occlusal interventions for managing temporomandibular disorders (2024) · Cochrane
MD -0.19 [-1.25, 0.87]1 study · 72 participantsVery low