Search review questions

Time to next/working arch wire · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)

Salivary S. mutans level · Humans with salivary bacteria measured · Overall

Dental caries prevalence · Adult residents of slums and non-slum urban settings of LMICs · Cross-sectional

Positive predictive value · Children and adults with primary or permanent dentition undergoing dental caries assessment · Cross-sectional diagnostic accuracy (index test vs reference standard, in-vivo), Overall (studies reporting PPV; narrative synthesis)

Oral cancer (OC) · Sensitivity analysis: excluding Moraes et al. [34]

Adverse effects · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Salivary pH · Children and/or adolescents (<18 years) without background systemic disease · follow-up: mean 1.1 months, Overall (all presentations pooled)

Adverse effects · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or… · 3 days

Self-esteem (Oral Aesthetic Subjective Impact Score, OASIS) · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · 3-year follow-up

Pathogenic bacteria / plaque composition around brackets (fewer pathogenic bacteria with flash-free vs APC; comparable plaque quantity)

Frequency of joint noise · People with temporomandibular disorders (TMD) · Short term (mean 10 weeks), Myofascial pain TMD

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · 3 to 6 months

Dental caries / early childhood caries (ECC) · Children (approx. 4-18 years) · Adjustment for sex: yes

Sensitivity · Children and adults with primary or permanent dentition undergoing dental caries assessment · Cross-sectional diagnostic accuracy (index test vs reference standard, in-vivo), Overall (studies reporting sensitivity; narrative synthesis)

Association between orthodontic treatment duration and ICLs incidence · Patients undergoing fixed orthodontic treatment with fixed (multibracket) appliances, followed for development of new… · During or after fixed orthodontic treatment, By orthodontic treatment duration (subgroup meta-analysis; positive association, P<.01)

Number of dental caries (carious pieces) · Children and/or adolescents (<18 years) without background systemic disease · follow-up: mean 26 months, Overall (all presentations pooled)

defs index score · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6…

Caries arrestment at the individual (patient) level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition) · 3 weeks to 12 months, SDF vs placebo

Caries arrest · Children and adults (with or without carious lesions) · 6 months, Primary dentition (coronal)

Secondary prevention of caries · Children and adults (with or without carious lesions) · 30 months, Primary dentition

Dental caries (early childhood caries) · Preschool children (<6 years) · Cohort studies

Change in Mutans streptococci (MS) count in dental plaque · Generally healthy individuals across all age groups (infants to elderly) · Post-consumption endpoint (trial durations 2 wk to 6 mo), Xylitol gum vs no treatment (5 studies, mixed ages)

Poor (inadequate) oral hygiene (prevalence) · Children (<18 years) with intellectual and developmental disabilities (IDD) in India · Overall

Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC)

Restoration/treatment success rate · Patients with deep carious lesions in permanent (mainly posterior) teeth · 1 to 5 years (follow-up varied by study)

Range of mandibular motion · People with temporomandibular disorders (TMD) · Short term (12 weeks), Mixed TMD

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC), Primary dentition

Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC), Asian ethnicity

Ion release (fluoride, calcium, phosphate) · Human enamel specimens around orthodontic brackets (in vitro) · 14 days [31] and 20 days [27,28] (per Discussion); ion-release durations for [23,24] not reported, Overall

Caries presence in primary teeth · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6… · Children assessed at 18-24 months

Streptococcus mutans count · Patients undergoing fixed orthodontic treatment · 1, 3, and 6 months after bonding

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · 3-year follow-up

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment

Participant satisfaction · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Biofilm formation (reduction) · Streptococcus mutans (in vitro cultures and biofilms)

Alignment rate · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch) · 4 to 16 weeks

dmft index score (decayed, missing, filled primary teeth; range 0-20) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,… · Children assessed at 4 yrs

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC), Asian ethnicity

Biofilm formation · Streptococcus mutans cultures and biofilms

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · Less than 3 months

Noticeable impact of gene sequencing on diagnosing/managing oral conditions · Human patients (any age) with oral-cavity related disorders (e.g. dental caries, periodontitis, gingivitis,… · Overall

Dental caries experience in permanent dentition · Nigerian individuals with permanent dentition (approximately 12 years and older) · Permanent dentition

Dental caries in children · Infants and children (aged about 2 to 8 years) whose mothers' vitamin D status was assessed during pregnancy · Prenatal exposure; dental caries assessed in children aged 2 to 8 years, Overall (all studies pooled)

Dental caries / early childhood caries (ECC) · Children (approx. 4-18 years) · Adjustment for sex: no

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months, Irreversible pulpitis

Proportion of teeth with non-carious cervical lesions (NCCLs) in ancient skulls · Ancient/prehistoric human skulls (excavated/archaeological skeletal remains) · Overall (all included studies)

Dental caries (prevalence) · Adults · Crude OR

Dental caries prevalence (any DMFT), dichotomous · Brazilian children/adolescents in permanent dentition (BMI classified by CDC 2000 growth charts)

Factors associated with oral diseases · Adult residents of slums and non-slum urban settings of LMICs · Cross-sectional