What do systematic reviews say?

Buffered vs non‐buffered crystalloid intravenous fluid

• Perioperative administration of buffered versus non‐buffered crystalloid intravenous fluid to improve outcomes… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 530 participants
  Moderate

Prophylactic dopamine antagonist antiemetic medications vs placebo

Prophylactic dopamine antagonist antiemetic medications showed no clear difference in vomiting (≥1 episode) compared with placebo (low certainty).

• Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting 2022 · Cochrane Headline outcomes only
  RR 1.18 [0.26, 5.32]
  3 studies · 527 participants
  Low

Prophylactic dopamine antagonist antiemetic medications vs placebo

Prophylactic dopamine antagonist antiemetic medications showed no clear difference in nausea (≥1 episode) compared with placebo (low certainty).

• Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting 2022 · Cochrane Headline outcomes only
  RR 0.55 [0.15, 2.03]
  2 studies · 336 participants
  Low

Prophylactic dopamine antagonist antiemetic medications vs placebo

Prophylactic dopamine antagonist antiemetic medications showed no clear difference in adverse events compared with placebo (low certainty).

• Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting 2022 · Cochrane Headline outcomes only
  RR 2.34 [0.47, 11.61]
  3 studies · 527 participants
  Low

Prophylactic dopamine antagonist antiemetic medications vs placebo

The review found no eligible studies for this question.

• Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Prophylactic dopamine antagonist antiemetic medications vs placebo

• Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 191 participants
  Low

Prophylactic dopamine antagonist antiemetic medications vs placebo

Prophylactic dopamine antagonist antiemetic medications showed no clear difference in rescue medication compared with placebo (low certainty).

• Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting 2022 · Cochrane Headline outcomes only
  RR 1.86 [0.17, 20.16]
  3 studies · 527 participants
  Low

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Summary of findings: single showed no clear difference in change in FEV1 % predicted at end of antibiotic course: absolute… compared with combination intravenous anti‐pseudomonal antibiotic therapy (low certainty).

• Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
  MD 5.25
  2 studies · 93 participants
  Low

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

The review found no eligible studies for this question.

• Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
• Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

The review found no eligible studies for this question.

• Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
• Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 131 participants
  Low

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

• Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  GRADE not reported

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Summary of findings: single showed no clear difference in change in sputum P aeruginosa density at end of treatment (cfu/g) compared with combination intravenous anti‐pseudomonal antibiotic therapy (moderate certainty).

• Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 76 participants
  Moderate
• Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

The review found no eligible studies for this question.

• Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
• Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

The review found no eligible studies for this question.

• Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

The review found no eligible studies for this question.

• Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Percutaneous vascular interventions vs intravenous thrombolytic treatment

Percutaneous vascular interventions showed no clear difference in good functional outcome (mRS score 0‐2) compared with intravenous thrombolytic treatment (low certainty).

• Percutaneous vascular interventions versus intravenous thrombolytic treatment for acute ischaemic stroke 2018 · Cochrane Headline outcomes only
  RR 1.01 [0.82, 1.25]
  3 studies · 443 participants
  Low

Percutaneous vascular interventions vs intravenous thrombolytic treatment

Percutaneous vascular interventions showed no clear difference in death compared with intravenous thrombolytic treatment (low certainty).

• Percutaneous vascular interventions versus intravenous thrombolytic treatment for acute ischaemic stroke 2018 · Cochrane Headline outcomes only
  RR 1.34 [0.84, 2.14]
  3 studies · 443 participants
  Low

Percutaneous vascular interventions vs intravenous thrombolytic treatment

Percutaneous vascular interventions showed no clear difference in symptomatic intracranial haemorrhage within first 14 days compared with intravenous thrombolytic treatment (low certainty).

• Percutaneous vascular interventions versus intravenous thrombolytic treatment for acute ischaemic stroke 2018 · Cochrane Headline outcomes only
  RR 0.99 [0.5, 1.95]
  4 studies · 450 participants
  Low

Percutaneous vascular interventions vs intravenous thrombolytic treatment

The review found no eligible studies for this question.

• Percutaneous vascular interventions versus intravenous thrombolytic treatment for acute ischaemic stroke 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Epidural analgesia vs intravenous patient‐controlled analgesia

• Epidural analgesia versus patient‐controlled intravenous analgesia for pain following intra‐abdominal surgery in adults 2018 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 384 participants
  Moderate