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Evidence found and GRADE certainty

2,227 questions · 2,562 findings · 156 reviews · Oral Health

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No studies found 297 · 11.6%GRADE not reported 1,616 · 63.1%Very low 405 · 15.8%Low 144 · 5.6%Moderate 81 · 3.2%High 19 · 0.7%

Malocclusion vs Absence/lower severity of malocclusion

Oral health-related quality of life · Adolescents (10-19 years)

Malocclusion is associated with worse oral health-related quality of life in adolescents (narrative synthesis; no pooled estimate or GRADE rating).

1 finding from 1 review

Favorable family structure (being an only child; nuclear family) vs Having siblings / non-nuclear family structure

Oral health-related quality of life · Adolescents (10-19 years)

Being an only child and growing up in a nuclear family are associated with better OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).

1 finding from 1 review
  • Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
    Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
    Being an only child, growing up in your nuclear family or family structure, household conditions, and number of people per household and maternal age are predictors of better OHRQoL [43].
    Studies not reported
    GRADE not reported

Treatment of traumatic dental injury vs Untreated dental trauma

Oral health-related quality of life · Adolescents (10-19 years)

Treating traumatic dental injuries reduces their negative impact on OHRQoL in adolescents (narrative synthesis; included review reports low certainty; no pooled estimate or GRADE rating by the umbrella review).

1 finding from 1 review
  • Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
    Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
    Treatment of TDI reduces the negative impact on OHRQoL in adolescents, based on parental perception [33]. Treatment of traumatic dental injuries reduces the impact on the OHRQoL with low evidence [46].
    Studies not reported
    GRADE not reported

0-19 remaining teeth vs Individuals without functional edentulism

Oral health-related quality of life · Indian elderly

Evidence on functional edentulism and OHRQoL is inconsistent across two studies (very low certainty).

2 findings from 1 review

Toothache vs No dental pain

Oral health-related quality of life · Adolescents (10-19 years)

Toothache/dental pain is associated with worse OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).

1 finding from 1 review
  • Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
    Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
    Toothache, DMT and tooth loss have a high impact on OHRQoL in adolescentes [26]. There is low evidence that dental pain has a negative impact on OHRQoL [37].
    Studies not reported
    GRADE not reported

Access to dental care / health services vs No / limited access to dental care

Oral health-related quality of life · Adolescents (10-19 years)

Access to dental care is associated with better OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).

1 finding from 1 review
  • Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
    Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
    having parents who can provide dental care and safe housing are positive predictors for OHRQoL. access to dental care and the performance of health promotion programs are directly proportional to OHRQoL in adolescents.
    Studies not reported
    GRADE not reported

Skin color / ethnicity vs Reference skin color / ethnicity

Oral health-related quality of life · Adolescents (10-19 years)

There is no concrete evidence on the impact of skin color/ethnicity on OHRQoL in adolescents (evidence gap; narrative synthesis; no pooled estimate or GRADE rating).

1 finding from 1 review
  • Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes
    Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
    Biological data such as skin color and age have no concrete evidence about this impact in the OHRQoL. Important aspects like gender and skin color did not have their level of impact clarified.
    Studies not reported
    GRADE not reported

Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs Healthy HIV-negative controls

Mucosal (oral) hyperpigmentation · Children or adolescents

CLWH on ART had significantly higher prevalence of mucosal hyperpigmentation than healthy controls (pooled OR 20.35, 95% CI 3.86 to 107.39); the authors described the certainty as low.

1 finding from 1 review

ART/HAART duration <3 years vs ART/HAART duration >=3 years

Other orofacial opportunistic infections (linear gingival erythema, hairy leukoplakia, angular cheilitis, oral ulcers) · Children and adolescents living with HIV on ART/HAART

ART/HAART duration had minimal influence on the prevalence of orofacial opportunistic infections other than candidiasis (no significant differences).

1 finding from 1 review
  • Oral Health Status of Children and Adolescents Living with HIV Undergoing Antiretroviral Therapy: A Systematic Review… 2022 All outcomes
    Cross-sectional (case-control; single time point) · HIV pediatric/ART clinics, AIDS centers, and hospitals in Brazil, India, Saudi Arabia, and West Africa (Cote d'Ivoire, Mali, Senegal) · ART/HAART duration <3 years vs >=3 years
    Except for candidiasis, no significant differences in the prevalence of opportunistic infection manifestations (linear gingival erythema, hairy leukoplakia, angular cheilitis, oral ulcers) between ART duration <3 years…
    2 studies
    GRADE not reported

Atraumatic restorative treatment vs placebo

Oral health-related quality of life · Children with dental caries

ART and placebo did not differ for oral health-related quality of life, based on an indirect network estimate with no direct trials (MD -0.01, 95% CI -0.40 to 0.38; ungraded).

3 findings from 1 review

CD4+ T-cell count below 250 cells/mm3

HIV-related oral lesions · Children living with HIV receiving ART

One reported study did not show a clear difference in HIV-related oral lesions for children with CD4+ T-cell counts below 250 cells/mm3.

2 findings from 1 review

Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs Healthy HIV-negative controls

Recurrent oral ulcerations (WHO clinical stage 2) · Children or adolescents

CLWH on ART had significantly higher prevalence of recurrent oral ulcerations than healthy controls (pooled OR 6.83, 95% CI 1.18 to 39.53).

1 finding from 1 review

Combined antiretroviral therapy (post-cART) vs Pre-cART (same children, before therapy)

Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

Oral candidiasis prevalence fell significantly after cART compared with before cART in the same children (very low certainty).

1 finding from 1 review

Placebo vs Silver diamine fluoride

Oral health-related quality of life · Children with dental caries

The direct estimate found no statistically significant difference in oral health-related quality of life between placebo and silver diamine fluoride.

2 findings from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Oral hygiene · Children and adolescents (<18 years) living with HIV (CLWH)

Oral hygiene status did not differ significantly between CLWH with and without ART (very low certainty).

1 finding from 1 review