Early childhood caries (ECC) - association with genetically predicted expression of LACC1 (chr13q14.11) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted LACC1 expression reached the TWAS threshold for ECC (p = 3.98e-5) but was flagged as a possible false positive (LD misspecification) and not further considered; ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of NRAD1 (LINC00284) (chr13q14.11) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted NRAD1 (LINC00284) expression reached the TWAS threshold for ECC (p = 1.69e-6) but was flagged as a possible false positive (LD misspecification) and not further considered; ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of TAS2R31 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of TAS2R31 was suggestively associated with ECC in the TWAS (p = 1.04e-5); genetic association, ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of TAS2R14 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of TAS2R14 was significantly associated with ECC in the TWAS (p = 1.06e-6); genetic association, ungraded.
1 finding from 1 review
Early childhood caries (ECC) · Healthy children under 6 years in South Africa
No significant difference in caries odds was found between bottle-fed-only and breast-fed-only children (meta-analysis reported no difference; pooled estimate in an unavailable supplementary figure; not GRADE-rated).
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of IGSF5 (chr21q22.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted IGSF5 expression reached the TWAS threshold for ECC (p = 7.22e-5) but was flagged as a possible false positive (LD misspecification) and not further considered; ungraded.
1 finding from 1 review
Early childhood caries (ECC) · Healthy children under 6 years in South Africa
No significant difference in caries odds was found between children of low- versus high-SES parents (meta-analysis reported no difference; pooled estimate in an unavailable supplementary figure; not GRADE-rated).
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of LINC02905 (C8orf49) (chr8p23.1) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted LINC02905 (C8orf49) expression reached the TWAS threshold for ECC (p = 1.82e-8) but was flagged as a possible false positive (LD misspecification) and not further considered; ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association at lead SNP rs74470773 (3:33958083; nearest gene(s) PDCD6IP) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
The common variant rs74470773 near PDCD6IP showed suggestive (not genome-wide significant) association with ECC (Z = -4.589, p = 4.46e-6); genetic association, ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of CDH17 (chr8q22.1) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of CDH17 was significantly associated with ECC in the TWAS (p = 3.32e-8); genetic association, ungraded.
1 finding from 1 review
Caries prevalence (early childhood caries) · Toddlers and preschool children, 2 to 6 years of age (primary dentition)
Caesarean section delivery may be associated with a modestly higher prevalence of early childhood caries than vaginal delivery (pooled OR 1.48), but the evidence is inconsistent and of very low certainty.
1 finding from 1 review
Early childhood caries (ECC) · Children aged 6 years or younger (preschool children)
Adjusted analyses also showed no association between low birth weight and early childhood caries (adjusted OR 1.05, 95% CI 0.71 to 1.57); certainty not graded.
3 findings from 1 review
Early childhood caries (ECC) · Children aged 6 years or younger (preschool children)
In children aged 3 years or younger, preterm birth was not associated with early childhood caries (OR 0.90, 95% CI 0.59 to 1.37); certainty not graded.
2 findings from 1 review
Early onset GBS disease (sepsis and/or meningitis within the first seven days of life)) · women with vaginal or rectal colonization with GBS during labour and their preterm/term infants
It is very uncertain whether chlorhexidine (vaginal wash or gel/cream) changes early onset GBS disease (sepsis and/or meningitis within the first… compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Neonatal mortality due to early‐onset GBS infection · women with vaginal or rectal colonization with GBS during labour and their preterm/term infants
1 finding from 1 review
Stage at diagnosis (early-stage detection) · Apparently healthy adults aged 35 years or older (general population), living in 13 clusters in rural areas of Trivandrum city, Kerala,…
Visual screening (oral visual inspection) by trained health workers led to lower stage at diagnosis (early-stage detection) compared with no screening; GRADE not reported.
2 findings from 1 review
Leaving the study early/ loss to · people with psychosis
1 finding from 1 review
Occurrence of CIP/CIM ‐ in the total population randomised · critically ill patients
Early physical therapy showed no clear difference in occurrence of CIP/CIM ‐ in the total population randomised compared with control (low certainty).
1 finding from 1 review
Occurrence of CIP/CIM ‐ in screened population · critically ill patients
Early physical therapy probably leads to lower occurrence of CIP/CIM ‐ in screened population compared with control (moderate certainty).
1 finding from 1 review
Serious adverse events ‐ in total population randomised · critically ill patients
Early physical therapy showed no clear difference in serious adverse events ‐ in total population randomised compared with control (moderate certainty).
1 finding from 1 review