Cochrane · systematic review · CD003520
Vaginal chlorhexidine during labour to prevent early‐onset neonatal group B streptococcal infection
Ohlsson, A, Shah, VS, Stade, BC · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 33.3%Very low 4 · 66.7%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Chlorhexidine (vaginal wash or gel/cream) versus placebo or no treatment
Population: women with vaginal or rectal colonization with GBS during labour and their preterm/term infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Early onset GBS disease (sepsis and/or meningitis within the first seven days of life)) Chlorhexidine (vaginal wash or gel/cream) vs placebo or no treatment | RR 2.32 [0.34, 15.63] | 2 studies · 987 participants | Very low Downgraded: imprecision |
GBS pneumonia within the first seven days of life Chlorhexidine (vaginal wash or gel/cream) vs placebo or no treatment | RR 0.35 [0.01, 8.6] | 2 studies · 987 participants | Very low Downgraded: imprecision |
Neonatal colonization with GBS within the first seven days of life Chlorhexidine (vaginal wash or gel/cream) vs placebo or no treatment | RR 0.64 [0.4, 1.01] | 3 studies · 328 participants | Very low Downgraded: imprecision |
Neonatal mortality due to early‐onset GBS infection Chlorhexidine (vaginal wash or gel/cream) vs placebo or no treatment | no estimate extracted | 1 study · 190 participants | Ungraded |
Adverse (mild) effects in the mother Chlorhexidine (vaginal wash or gel/cream) vs placebo or no treatment | RR 8.5 [1.6, 45.28] | 3 studies · 1066 participants | Very low Downgraded: imprecision |
Adverse (mild) effects in the neonate Chlorhexidine (vaginal wash or gel/cream) vs placebo or no treatment | no estimate extracted | 3 studies · 1066 participants | Ungraded |