Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

564 questions · 589 findings · 155 reviews · Headline outcomes only

No studies found 114 · 19.4%GRADE not reported 15 · 2.5%Very low 179 · 30.4%Low 141 · 23.9%Moderate 110 · 18.7%High 30 · 5.1%

Perazine vs placebo

Leaving the study early · patients with schizophrenia

It is very uncertain whether perazine changes acceptability of treatment Leaving the study early due to any reason compared with placebo (very low certainty).

1 finding from 1 review

Perazine vs OTHER ANTIPSYCHOTICS

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

Perazine showed no clear difference in acceptability of treatment Leaving the studies early due to any reason compared with other antipsychotics (low certainty).

1 finding from 1 review

Surgical interventions (exploration and decompression / external neurolysis, internal neurolysis, neurorrhaphy / direct repair, neuroma excision, anastomosis, autologous or allograft nerve grafting or tubulization) vs conservative interventions

Unacceptable malunion · Children and adolescents with femoral shaft fractures

Surgical interventions probably leads to lower unacceptable malunion Assessed by imaging compared with conservative interventions (moderate certainty).

1 finding from 1 review

rTMS + pharmacotherapy vs sham rTMS + pharmacotherapy

Acceptability ‐ total dropouts · participants with panic disorder

It is very uncertain whether rTMS + pharmacotherapy changes acceptability: dropouts for any reason number of dropouts compared with sham rTMS + pharmacotherapy (very low certainty).

1 finding from 1 review

rTMS + pharmacotherapy vs sham rTMS + pharmacotherapy

Acceptability ‐ dropouts due to adverse effects · participants with panic disorder

It is very uncertain whether rTMS + pharmacotherapy changes acceptability: dropouts for adverse effects number of dropouts compared with sham rTMS + pharmacotherapy (very low certainty).

1 finding from 1 review

FLUPHENAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

FLUPHENAZINE showed no clear difference in acceptability of treatment‐leaving the study early due to any reason compared with LOW‐POTENCY ANTIPSYCHOTIC DRUGS (moderate certainty).

1 finding from 1 review

PERPHENAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

It is very uncertain whether comparison 1: PERPHENAZINE changes acceptability of treatment ‐ leaving the study early due to any reason compared with LOW‐POTENCY ANTIPSYCHOTIC DRUGS (very low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

Trifluoperazine showed no clear difference in leaving the study early: 1. Acceptability of treatment ‐ leaving… compared with low‐potency antipsychotic drugs (low certainty).

1 finding from 1 review

INFORMATION AND COMMUNICATION TECHNOLOGY (ICT) FOR PROMPTING/SUPPORT + STANDARD CARE vs usual care

Acceptability (of intervention): Leaving the studies early – any reason Loss to · patients with treatment compliance for people with serious mental illness

INFORMATION AND COMMUNICATION TECHNOLOGY (ICT) FOR PROMPTING/SUPPORT… showed no clear difference in acceptability (of intervention): Leaving the studies early – any… compared with STANDARD CARE (low certainty).

1 finding from 1 review

Canakinumab vs triamcinolone acetonide

Global assessment of treatment success · acute gout

Canakinumab probably leads to higher participant global assessment of response to treatment: good or… compared with triamcinolone acetonide (moderate certainty).

1 finding from 1 review

Psychological therapy vs Waitlist/Usual Care

Secondary outcome: acceptability of treatment · people with somatoform disorders and medically unexplained physical symptoms

Psychological therapy probably leads to lower acceptability 1 ‐ proportion of participants withdrawing during… compared with usual care or waiting list (moderate certainty).

1 finding from 1 review