Serious maternal morbidity or death · women with one previous lower segment caesarean section and requiring labour induction due to prolonged pregnancy or pre‐eclampsia,…
Vaginal PGE2 showed no clear difference in serious maternal morbidity or death compared with intravenous (IV) oxytocin (low certainty).
1 finding from 1 review
Uterine hyperstimulation with fetal heart rate changes · patients with induction of labour at term
PGE2 probably leads to higher uterine hyperstimulation with FHR changes compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Caesarean section · patients with induction of labour at term
PGE2 showed no clear difference in caesarean section compared with placebo or no treatment (high certainty).
1 finding from 1 review
Serious neonatal morbidity or perinatal death · patients with induction of labour at term
PGE2 showed no clear difference in serious neonatal morbidity or perinatal death compared with placebo or no treatment (low certainty).
1 finding from 1 review
Serious maternal morbidity or death · patients with induction of labour at term
It is very uncertain whether PGE2 changes serious maternal morbidity or death compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Uterine hyperstimulation with fetal heart rate changes · patients with induction of labour at term
It is very uncertain whether (4.1) PGE2 gel changes uterine hyperstimulation with FHR changes compared with PGE2 tablet (all women) (very low certainty).
1 finding from 1 review
Caesarean section · patients with induction of labour at term
(4.1) PGE2 gel showed no clear difference in caesarean section compared with PGE2 tablet (all women) (high certainty).
1 finding from 1 review
Serious maternal morbidity or death · patients with induction of labour at term
(4.1) PGE2 gel showed no clear difference in serious maternal morbidity or death compared with PGE2 tablet (all women); GRADE not reported.
1 finding from 1 review
Uterine hyperstimulation with fetal heart rate changes · patients with induction of labour at term
(7.1) PGE2 (controlled release) showed no clear difference in uterine hyperstimulation with FHR changes compared with all PGE2 delivery systems (all women) (moderate certainty).
1 finding from 1 review
Caesarean section · patients with induction of labour at term
(7.1) PGE2 (controlled release) showed no clear difference in caesarean section compared with all PGE2 delivery systems (all women) (moderate certainty).
1 finding from 1 review
Serious neonatal morbidity or perinatal death · patients with induction of labour at term
(7.1) PGE2 (controlled release) showed no clear difference in serious neonatal morbidity or perinatal death compared with all PGE2 delivery systems (all women) (low certainty).
1 finding from 1 review
Vaginal delivery not achieved within 24 hours · women requiring induction of labour
1 finding from 1 review
Vaginal birth not achieved in 48 to 72 h · women requiring induction of labour
Intracervical PGE₂ showed no clear difference in vaginal birth not achieved in 48 to 72 h compared with placebo (low certainty).
1 finding from 1 review
Spontaneous vaginal birth · women having induction of labour at term
It is very uncertain whether home changes spontaneous vaginal birth№ of participants: 1022(2 RCTs) compared with inpatient induction with vaginal PGE (very low certainty).
1 finding from 1 review
RR 0.91 [0.69, 1.21]
Studies not reported
Very low
Vaginal delivery not achieved within 24 hours · women with a previous caesarean section (subgroup of all women in the study) with intact fetal membranes, cephalic position and…
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Spontaneous vaginal birth · women having induction of labour at term
It is very uncertain whether home changes spontaneous vaginal birth№ of participants: 299(1 RCT) compared with inpatient induction with controlled release PGE (very low certainty).
1 finding from 1 review
RR 0.94 [0.77, 1.14]
Studies not reported
Very low
Uterine hyperstimulation№ of participants: 299(1 RCT) · women having induction of labour at term
It is very uncertain whether home changes uterine hyperstimulation№ of participants: 821(1 RCT) compared with inpatient induction with vaginal PGE (very low certainty).
1 finding from 1 review
RR 1.19 [0.4, 3.5]
Studies not reported
Very low
Caesarean section · women having induction of labour at term
It is very uncertain whether home changes caesarean birth№ of participants: 1022(2 RCTs) compared with inpatient induction with vaginal PGE (very low certainty).
1 finding from 1 review
RR 1.01 [0.81, 1.28]
Studies not reported
Very low
Neonatal infection · women having induction of labour at term
It is very uncertain whether home changes neonatal infection (up to 28 days)№ of participants: 821(1 RCT) compared with inpatient induction with vaginal PGE (very low certainty).
1 finding from 1 review
RR 1.29 [0.59, 2.82]
Studies not reported
Very low
Admission to neonatal intensive care unit · women having induction of labour at term
It is very uncertain whether home changes admission to NICU№ of participants: 1022(2 RCTs) compared with inpatient induction with vaginal PGE (very low certainty).
1 finding from 1 review
RR 1.2 [0.5, 2.9]
Studies not reported
Very low