Cochrane · systematic review · CD007701
Pharmacological and mechanical interventions for labour induction in outpatient settings
Vogel, JP, Osoti, AO, Kelly, AJ, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
11
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 10 · 47.6%Very low 0 · 0%Low 10 · 47.6%Moderate 1 · 4.8%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Vaginal PGE₂ compared to placebo or expectant management for the induction of labour in outpatient settings
Population: women requiring term labour induction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Vaginal birth not achieved within 24 h Vaginal PGE₂ vs placebo or expectant management | no estimate extracted | 0 studies · 0 participants | Ungraded |
Vaginal birth not achieved in 48 to 72 h Vaginal PGE₂ vs placebo or expectant management | no estimate extracted | 0 studies · 0 participants | Ungraded |
Uterine hyperstimulation (fetal heart rate changes unclear) Vaginal PGE₂ vs placebo or expectant management | RR 3.76 [0.64, 22.24] | 4 studies · 244 participants | Low Downgraded: imprecision |
Caesarean section Vaginal PGE₂ vs placebo or expectant management | RR 0.8 [0.49, 1.31] | 4 studies · 288 participants | Low Downgraded: imprecision |
Serious neonatal morbidity or death Vaginal PGE₂ vs placebo or expectant management | no estimate extracted | 0 studies · 0 participants | Ungraded |
Serious maternal morbidity or death Vaginal PGE₂ vs placebo or expectant management | no estimate extracted | 0 studies · 0 participants | Ungraded |
Neonatal intensive care unit admission Vaginal PGE₂ vs placebo or expectant management | RR 0.32 [0.1, 1.03] | 3 studies · 230 participants | Low Downgraded: imprecision |
Intracervical PGE₂ compared to placebo for the induction of labour in outpatient settings
Population: women requiring induction of labour
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Vaginal birth not achieved within 24 h Intracervical PGE₂ vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Vaginal birth not achieved in 48 to 72 h Intracervical PGE₂ vs placebo | RR 0.83 [0.68, 1.02] | 1 study · 43 participants | Low Downgraded: imprecision |
Uterine hyperstimulation (with fetal heart rate changes) Intracervical PGE₂ vs placebo | RR 2.66 [0.63, 11.25] | 4 studies · 488 participants | Low Downgraded: imprecision |
Caesarean section Intracervical PGE₂ vs placebo | RR 0.9 [0.72, 1.12] | 7 studies · 674 participants | Moderate Downgraded: imprecision |
Serious neonatal morbidity or death Intracervical PGE₂ vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Serious maternal morbidity or death Intracervical PGE₂ vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Neonatal intensive care unit admission Intracervical PGE₂ vs placebo | RR 1.61 [0.43, 6.05] | 3 studies · 215 participants | Low Downgraded: imprecision |
Vaginal misoprostol compared to placebo for the induction of labour in outpatient settings
Population: women requiring induction of labour
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Vaginal birth not achieved within 24 h Vaginal misoprostol vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Vaginal birth not achieved within 48 and 72 h Vaginal misoprostol vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Uterine hyperstimulation (with fetal heart rate changes) Vaginal misoprostol vs placebo | RR 1.97 [0.43, 9] | 3 studies · 265 participants | Low Downgraded: imprecision |
Caesarean section Vaginal misoprostol vs placebo | RR 0.94 [0.61, 1.46] | 4 studies · 325 participants | Low Downgraded: imprecision |
Serious neonatal morbidity or death Vaginal misoprostol vs placebo | RR 0.34 [0.01, 8.14] | 1 study · 77 participants | Low Downgraded: imprecision |
Serious maternal morbidity or death Vaginal misoprostol vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Neonatal intensive care unit admission Vaginal misoprostol vs placebo | RR 0.89 [0.54, 1.47] | 4 studies · 325 participants | Low Downgraded: imprecision |