Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

46 questions · 46 findings · 4 reviews

No studies found 11 · 23.9%GRADE not reported 6 · 13%Very low 12 · 26.1%Low 9 · 19.6%Moderate 6 · 13%High 2 · 4.3%

Vaginal PGE₂ vs placebo or expectant management

Uterine hyperstimulation (fetal heart rate changes unclear) · patients with induction of labour at term

Vaginal PGE₂ showed no clear difference in uterine hyperstimulation (fetal heart rate changes unclear) compared with placebo or expectant management (low certainty).

1 finding from 1 review

Vaginal PGE2 pessary vs vaginal PGE2

Caesarean section · women with a previous caesarean section, a live singleton fetus (37‐42 weeks of gestation) in cephalic presentation and a reactive…

It is very uncertain whether vaginal PGE2 pessary changes caesarean section compared with vaginal PGE2 tablet (very low certainty).

1 finding from 1 review

(7.1) PGE2 (controlled release) vs all PGE2 delivery systems (all women)

Vaginal delivery not achieved within 24 hours · patients with induction of labour at term

(7.1) PGE2 (controlled release) showed no clear difference in vaginal delivery not achieved within 24 hours compared with all PGE2 delivery systems (all women) (moderate certainty).

1 finding from 1 review

Vaginal PGE2 vs intravenous (IV) oxytocin

Caesarean section · women with one previous lower segment caesarean section and requiring labour induction due to prolonged pregnancy or pre‐eclampsia,…

Vaginal PGE2 showed no clear difference in caesarean section compared with intravenous (IV) oxytocin (low certainty).

1 finding from 1 review

Vaginal PGE2 vs intravenous (IV) oxytocin

Serious neonatal morbidity or perinatal death · women with one previous lower segment caesarean section and requiring labour induction due to prolonged pregnancy or pre‐eclampsia,…

Vaginal PGE2 showed no clear difference in serious neonatal morbidity/perinatal death compared with intravenous (IV) oxytocin (low certainty).

1 finding from 1 review