Cochrane · systematic review · CD003101
Vaginal prostaglandin (PGE2 and PGF2a) for induction of labour at term
Thomas, J, Fairclough, A, Kavanagh, J, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
13
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 7.1%Very low 3 · 21.4%Low 2 · 14.3%Moderate 6 · 42.9%High 2 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
PGE2 compared with placebo or no treatment for induction of labour at term (all women)
Population: patients with induction of labour at term
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Vaginal delivery not achieved within 24 hours PGE2 vs placebo or no treatment | RR 0.32 [0.02, 4.83] | 2 studies · 384 participants | Very low |
Uterine hyperstimulation with FHR changes PGE2 vs placebo or no treatment | RR 3.16 [1.67, 5.98] | 15 studies · 1359 participants | Moderate |
Caesarean section PGE2 vs placebo or no treatment | RR 0.91 [0.81, 1.02] | 36 studies · 6599 participants | High |
Serious neonatal morbidity or perinatal death PGE2 vs placebo or no treatment | RR 0.46 [0.09, 2.31] | 9 studies · 3638 participants | Low |
Serious maternal morbidity or death PGE2 vs placebo or no treatment | RR 2.23 [0.34, 14.76] | 3 studies · 530 participants | Very low |
(4.1) PGE2 gel compared with PGE2 tablet (all women) for induction of labour at term
Population: patients with induction of labour at term
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Vaginal delivery not achieved within 24 hours (4.1) PGE2 gel vs PGE2 tablet (all women) | RR 1.03 [0.84, 1.26] | 3 studies · 566 participants | Moderate |
Uterine hyperstimulation with FHR changes (4.1) PGE2 gel vs PGE2 tablet (all women) | RR 2 [0.18, 21.71] | 1 study · 200 participants | Very low |
Caesarean section (4.1) PGE2 gel vs PGE2 tablet (all women) | RR 0.91 [0.72, 1.17] | 6 studies · 1046 participants | High |
Serious maternal morbidity or death (4.1) PGE2 gel vs PGE2 tablet (all women) | RR 0.33 [0.01, 8.09] | 1 study · 200 participants | Ungraded |
Instrumental vaginal delivery (4.1) PGE2 gel vs PGE2 tablet (all women) | RR 0.77 [0.58, 1.02] | 3 studies · 565 participants | Moderate |
(7.1) PGE2 (controlled release) compared with all PGE2 delivery systems (all women) for induction of labour at term
Population: patients with induction of labour at term
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Vaginal delivery not achieved within 24 hours (7.1) PGE2 (controlled release) vs all PGE2 delivery systems (all women) | RR 1.15 [0.92, 1.45] | 3 studies · 450 participants | Moderate |
Uterine hyperstimulation with FHR changes (7.1) PGE2 (controlled release) vs all PGE2 delivery systems (all women) | RR 2.15 [0.89, 5.21] | 5 studies · 643 participants | Moderate |
Caesarean section (7.1) PGE2 (controlled release) vs all PGE2 delivery systems (all women) | RR 1.02 [0.82, 1.26] | 11 studies · 1262 participants | Moderate |
Serious neonatal morbidity or perinatal death (7.1) PGE2 (controlled release) vs all PGE2 delivery systems (all women) | RR 0.31 [0.01, 7.62] | 2 studies · 320 participants | Low |