Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

186 questions · 191 findings · 36 reviews · Headline outcomes only

No studies found 19 · 9.9%GRADE not reported 13 · 6.8%Very low 68 · 35.6%Low 55 · 28.8%Moderate 26 · 13.6%High 10 · 5.2%

Tailored interventions based on sputum eosinophils vs tailored interventions based on clinical symptoms

Hospital admissions · people with asthma

Tailored interventions based on sputum eosinophils probably leads to lower hospitalisations compared with tailored interventions based on clinical symptoms (moderate certainty).

1 finding from 1 review

Cooling treatment (ice pack) vs placebo (water pack)

Maternal views and experiences with treatment ‐ Would repeat treatment in future childbirth · Women with perineal trauma (tear or episiotomy, or both) sustained during childbirth

It is very uncertain whether cooling treatment (ice pack) changes maternal views and experiences with treatment ‐ Would repeat… compared with placebo (water pack) (very low certainty).

1 finding from 1 review

Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs placebo or no intervention

Anaemia · preschool and school‐age children

Point‐of‐use fortification of foods with micronutrients powders (MNP) probably leads to lower anaemia (defined as haemoglobin < 110 g/L for children aged 24‐59… compared with no intervention or placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of subjects who had one or more exacerbations over the study period in children and adolescents ( · Adults and children with asthma

The intervention showed no clear difference in number of subjects who had one or more exacerbations over the study… (moderate certainty).

1 finding from 1 review

Summary of findings table – disulfiram vs placebo or no pharmacological treatment

Continuous abstinence from cocaine (number of participants who had achieved and maintained abstinence for at least three weeks at the end of treatment) · patients with the treatment of cocaine dependence

Summary of findings table – disulfiram showed no clear difference in continuous abstinence from cocaine (number of participants who had… compared with placebo or no pharmacological treatment (low certainty).

1 finding from 1 review

Intervention not reported

Proportion of patients achieving and maintaining undetectable viral load, e.g. less than 400 copies/ml · HIV infected adults who meet the WHO criteria for commencing antiretroviral treatment.

The intervention may leads to higher proportion of patients achieving and maintaining undetectable viral… (low certainty).

1 finding from 1 review

Intervention not reported

Proportion of patients achieving and maintaining undetectable viral load, e.g. less than 50 copies/ml · HIV infected adults who meet the WHO criteria for commencing antiretroviral treatment.

The intervention may leads to higher proportion of patients achieving and maintaining undetectable viral… (low certainty).

1 finding from 1 review

Tailoring asthma treatment using FeNO vs clinical symptoms

Asthma exacerbations · children with asthma

It is very uncertain whether tailoring asthma treatment using fractional exhaled nitric oxide changes number of asthma exacerbations per 52 weeks (exacerbation rate) compared with clinical symptoms (very low certainty).

1 finding from 1 review