Cochrane · systematic review · CD007276
Effectiveness and safety of first-line tenofovir + emtricitabine + efavirenz for patients with HIV
Omeje Innocent, Okwundu Charles I · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
HIV/AIDSAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
3
No studies
1
Included studies
NR
No studies 1 · 25%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 75%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Effectiveness and safety of first‐line TDF + FTC + EFV for patients with HIV
Population: HIV infected adults who meet the WHO criteria for commencing antiretroviral treatment.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death (all cause) | RR 0.5 [0.05, 5.46] | 1 study · 487 participants | Low Downgraded: risk of bias, imprecision |
Proportion of patients achieving and maintaining undetectable viral load, e.g. less than 400 copies/ml | RR 1.16 | 1 study · 487 participants | Low Downgraded: risk of bias, imprecision |
Proportion of patients achieving and maintaining undetectable viral load, e.g. less than 50 copies/ml | RR 1.13 [1.02, 1.25] | 1 study · 487 participants | Low Downgraded: risk of bias, imprecision |
CD4+ count | no estimate extracted | NR | No studies |