Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

140 questions · 147 findings · 26 reviews · Emergency and Critical Care

No studies found 24 · 16.3%GRADE not reported 2 · 1.4%Very low 56 · 38.1%Low 43 · 29.3%Moderate 12 · 8.2%High 10 · 6.8%

Bispectral index vs treatment guided by clinical assessment alone?

Duration of mechanical ventilation · Mechanically ventilated adults in the intensive care unit

BIS monitoring showed no clear difference in duration of mechanical ventilation (measured in days) compared with clinical assessment (low certainty).

1 finding from 1 review

Dopamine vs norepinephrine

Total mortalitya · hypotensive shock

Dopamine showed no clear difference in total mortalitya compared with norepinephrine (high certainty).

1 finding from 1 review

Terlipressin vs norepinephrine

Total mortalitya · hypotensive shock

It is very uncertain whether terlipressin changes total mortalitya compared with norepinephrine (very low certainty).

1 finding from 1 review

Vasopressin vs norepinephrine

Total mortalitya · hypotensive shock

Vasopressin showed no clear difference in total mortalitya compared with norepinephrine (moderate certainty).

1 finding from 1 review

Phenylephrine vs norepinephrine

Total mortalitya · hypotensive shock

It is very uncertain whether phenylephrine changes total mortalitya compared with norepinephrine (very low certainty).

1 finding from 1 review

Epinephrine vs norepinephrine

Total mortalitya · hypotensive shock

Epinephrine showed no clear difference in total mortalitya compared with norepinephrine (low certainty).

1 finding from 1 review

Intervention not reported

Combined mortality of all studies · Adult patients in intensive care

The intervention leads to higher combined mortality of all studies (high certainty).

1 finding from 1 review